Date of Award
Doctor of Philosophy (PhD)
Jablonski , Monica M., PhD
Almoazen, Hassan, PhD Majumdar, Soumyajit, PhD Mandal, Nawajes, PhD Meibohm, Bernd, PhD, FCP, FAAPS
Persistent or repeated elevation of intraocular pressure (IOP) is a primary risk factor of visual field loss in glaucoma, therefore IOP reduction is the first-line therapeutic option in the disease management. Unfortunately, the current therapies are associated with a lot of deficiencies including several daily dosing, reduced efficacy and systemic side effects all of which resulted in poor patient compliance. Previously we have identified Calcium voltage-gated channel auxiliary subunit Alpha2delta 1 gene (Cacna2d1) as a novel modulator of IOP and confirmed that pregabalin targeted CACNA2D1 in eye tissues (ciliary body and trabecular meshwork) to lower IOP in a dose-dependent manner. The research presented in this dissertation aimed to develop a once-daily ocular pregabalin-loaded multiple water-in-oil-in-water microemulsion eye drops. Several in vitro and in vivo evaluations were used to characterize the prepared ophthalmic formulations. Also stability study at 5°C, 25°C, 30°C and 40°C was conducted for four months. All the formulations components were carefully selected to be highly biocompatible that provided a highly transparent eye drops with a miniscule droplet size (
Maria, Doaa Nabih Ahmed (http://orcid.org/0000-0003-2845-5237), "Development of Multiple Microemulsion Eye Drops for Sustained Release of New Glaucoma Drug" (2018). Theses and Dissertations (ETD). Paper 466. http://dx.doi.org/10.21007/etd.cghs.2018.0473.
Available for download on Saturday, December 12, 2020