Date of Award
Doctor of Philosophy (PhD)
Jablonski , Monica M., PhD
Almoazen, Hassan, PhD Majumdar, Soumyajit, PhD Mandal, Nawajes, PhD Meibohm, Bernd, PhD, FCP, FAAPS
Dutch belted rabbits, Glaucoma, Intraocular pressure, Microemulsion, Stability, Transcorneal permeability
Persistent or repeated elevation of intraocular pressure (IOP) is a primary risk factor of visual field loss in glaucoma, therefore IOP reduction is the first-line therapeutic option in the disease management. Unfortunately, the current therapies are associated with a lot of deficiencies including several daily dosing, reduced efficacy and systemic side effects all of which resulted in poor patient compliance. Previously we have identified Calcium voltage-gated channel auxiliary subunit Alpha2delta 1 gene (Cacna2d1) as a novel modulator of IOP and confirmed that pregabalin targeted CACNA2D1 in eye tissues (ciliary body and trabecular meshwork) to lower IOP in a dose-dependent manner. The research presented in this dissertation aimed to develop a once-daily ocular pregabalin-loaded multiple water-in-oil-in-water microemulsion eye drops. Several in vitro and in vivo evaluations were used to characterize the prepared ophthalmic formulations. Also stability study at 5°C, 25°C, 30°C and 40°C was conducted for four months. All the formulations components were carefully selected to be highly biocompatible that provided a highly transparent eye drops with a miniscule droplet size (
Maria, Doaa Nabih Ahmed (http://orcid.org/0000-0003-2845-5237), "Development of Multiple Microemulsion Eye Drops for Sustained Release of New Glaucoma Drug" (2018). Theses and Dissertations (ETD). Paper 466. http://dx.doi.org/10.21007/etd.cghs.2018.0473.