Date of Award
Doctor of Philosophy (PhD)
Cancer and Developmental Biology
Junming Yue, PhD
Zheng Fan, PhD Ramesh Narayanan, PhD Lawrence M. Pfeffer, PhD Zhaohui Wu, PhD
Deoxyhypusine synthase, EIF5A, Epithelial to mesenchymal transition, Hypusination, Ovarian cancer, TGFβ
Ovarian cancer has the highest mortality rate among all gynecological malignancies due to lack of effective biomarkers for early diagnosis. The majority of ovarian cancer patients are already at an advanced stage when diagnosed. In addition, ovarian cancers often become chemoresistant and metastatic, and recur following initial chemotherapy.
Zhao, Guannan (https://orcid.org/0000-0003-3155-8528), "Eukaryotic Initiation Factor 5A2 (EIF5A2) Contributes to Ovarian Tumor Growth and Metastasis" (2020). Theses and Dissertations (ETD). Paper 536. http://dx.doi.org/10.21007/etd.cghs.2020.0521.