Publication Date

Summer 8-6-2022

Project Category

Health Research

Faculty Mentor

M. Boyd Gillespie, MD

Document Type



Objectives: To determine whether Drug-Induced Sleep Endoscopy (DISE) findings of Laryngopharyngeal Reflux (LPR) correlate with obesity, gender, Epworth Sleepiness scale, and OSA severity.

Study design: Single center retrospective cohort study.

Methods: Patients greater than 18 years of age who underwent DISE by one surgeon at a tertiary care center from July 2016 to July 2022 were included. DISE findings, patient characteristics, demographics, polysomnogram(s), and Epworth Sleepiness Scale(s) were extracted. Fisher’s exact test was used to compare categorical variables, and independent sample t-test was used to compare continuous variables. All statistical analyses were performed using IBM SPSS Statistics 28.

Results: The study included 178 patients (60.87 years ± 11.54; 31.24 BMI ± 6.21). 38 patients had LPR, and 103 patients had a BMI>30. LPR+ patients BMI was 33.11 ± 5.60, and LPR- patients BMI was 30.74 ± 6.28. There was a statistically significant relationship between obesity and LPR (p = 0.005). Additionally, obesity mild-moderately affected patients having LPR (d = .404). There was no statistically significant difference between LPR+ patients and ESS, AHI, and gender (p = .395, .174, & .302 respectively).

Conclusion: DISE aids in the diagnosis and evaluation of Obstructive Sleep Apnea (OSA) by simulating natural sleep. Using this highly precise diagnostic procedure, our study shows a relationship between findings of LPR in obese patients with obesity playing a small-medium role. There was no difference between LPR and ESS, AHI, and gender.