Rajashekhar Gangaraju, PhD
Following a traumatic brain injury, microglia become overactive for long periods and display pathologic behavior. We have shown that concentrated conditioned media from adipose tissue-derived mesenchymal stem cells (MSC-CCM) can suppress microglial activation. In this pilot study, we evaluated the efficacy of exosomes containing TNF-stimulated gene 6 (TSG6) derived from MSC-CCM on decreasing microglial activation in vitro via phagocytic activity and pro-inflammatory microglial gene expression.
Martinez, Jonathan A. and Gangaraju, Rajashekhar MD , "The Effects of Exosomal Derived TSG-6 on Microglia Activation" (2023). Longitudinal Scholar's Project. Paper 22. http://dx.doi.org/10.21007/com.lsp.2023.0019.