Eukaryotic Initiation Factor 5A2 (EIF5A2) Contributes to Ovarian Tumor Growth and Metastasis

Author

Guannan Zhao, University of Tennessee Health Science Center

Date of Award

11-2020

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

Program

Biomedical Sciences

Track

Cancer and Developmental Biology

Research Advisor

Junming Yue, PhD

Committee

Zheng Fan, PhD Ramesh Narayanan, PhD Lawrence M. Pfeffer, PhD Zhaohui Wu, PhD

Keywords

Deoxyhypusine synthase, EIF5A, Epithelial to mesenchymal transition, Hypusination, Ovarian cancer, TGFβ

Abstract

Ovarian cancer has the highest mortality rate among all gynecological malignancies due to lack of effective biomarkers for early diagnosis. The majority of ovarian cancer patients are already at an advanced stage when diagnosed. In addition, ovarian cancers often become chemoresistant and metastatic, and recur following initial chemotherapy.

Declaration of Authorship

Declaration of Authorship is included in the supplemental files.

ORCID

https://orcid.org/0000-0003-3155-8528

DOI

10.21007/etd.cghs.2020.0521

Recommended Citation

Zhao, Guannan (https://orcid.org/0000-0003-3155-8528), "Eukaryotic Initiation Factor 5A2 (EIF5A2) Contributes to Ovarian Tumor Growth and Metastasis" (2020). Theses and Dissertations (ETD). Paper 536. http://dx.doi.org/10.21007/etd.cghs.2020.0521.
https://dc.uthsc.edu/dissertations/536