Date of Award

2024

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

Program

Biomedical Sciences

Track

Microbiology, Immunology, and Biochemistry

Research Advisor

Maureen McGargill, PhD

Committee

Paul Thomas, PhD; Stacey Schultz-Cherry, PhD; Tony Marion, PhD; Tudor Moldoveanu, PhD

Keywords

antibody, autoimmunity, B-1 B cell, CD1d, influenza A virus, SARS-CoV-2

Abstract

Antibodies produced by B cells are crucial for eliminating infectious pathogens and preventing secondary infection. However, antibodies may also bind to self-antigens and contribute to autoimmune disease. While pathogen infections have been associated with development of autoimmune diseases, the precise contributions of viral infections to autoimmunity remain elusive. The presence of autoreactive antibodies is associated with an increased risk of developing autoimmune disease. Thus, analyzing the impact of viral infection and vaccination on the development of autoreactive antibodies will provide essential insight into mechanisms that contribute to autoimmune disease.

Declaration of Authorship

Declaration of Authorship is included in the supplemental files.

ORCID

0000-0002-3064-0178

DOI

10.21007/etd.cghs.2024.0666

Additional Files
2024-008-Lin-DOA.pdf (267 kB)
Declaration of Authorship
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