Pathogenesis of arthritis following the intravenous injection of staphylococci in the adult rabbit

UTHSC Affiliation

College of Medicine

Document Type

Article

Publication Date

6-20-1942

Publication Title

Journal of the American Medical Association

Volume

119

Issue

8

Abstract

The pathogenesis of the purulent arthritis following the intravenous injection of a broth culture of Staphylococcus aureus into the adult rabbit is discussed. It is suggested that the bacteria pass directly through the blood stream to the synovial membranes. The articular cartilage is eroded subsequently to the formation of the purulent exudate. Staphylococci may invade the epiphysis secondarily through the erosions in the articular cartilage. The number of joints involved and the frequency of arthritis in the normal and immune rabbit apparently is influenced by the number of bacteria circulating in the blood stream. The arthritis which develops following the intravenous inoculation of staphylococci is similar to the lesion that occurs after the intra-articular injection of the same organism. There is apparently no association between the strain of staphylococci used in this study and the development of lesions in bone. It is suggested that there is insufficient evidence at this time to warrent a classification of "osteomyelitic strains of staphylococci.". © 1942.

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