The involvement of the nervous system in sickle-cell anemia
Document Type
Article
Publication Date
1-1-1940
Publication Title
American Journal of Obstetrics and Gynecology
Volume
39
Issue
4
Abstract
Central nervous system involvement is a frequent occurrence in sickle-cell anemia. Reports of six new cases, two with autopsy, are presented, and the available literature including twenty-five other cases is reviewed. The clinical manifestations and spinal fluid findings are summarized. The essential pathology in the brain in sickle-cell anemia is similar to the pathology in other organs. The lesions are multiple and widespread but are mainly localized in the peripheral cortex and meninges. We consider the lesions to be primarily intravascular and due to thrombosis, following which there are extension of the thrombotic process and hemorrhagic, degenerative, and atrophic changes. Prognosis is poor, but variable and unpredictable. No effective form of treatment has been found. © 1940 The C. V. Mosby Company.
Recommended Citation
Hughes, J.,
Diggs, L.,
&
Gillespie, C.
(1940).
The involvement of the nervous system in sickle-cell anemia.
American Journal of Obstetrics and Gynecology,
39(4).
http://doi.org/10.1016/S0002-9378(40)90392-1
Retrieved from: https://dc.uthsc.edu/fac_pubs/176