The Treatment of Trichomonas vaginalis Vaginitis with Aureomycin

UTHSC Affiliation

College of Medicine

Document Type

Article

Publication Date

1-1-1948

Publication Title

Proceedings of the Society for Experimental Biology and Medicine

Volume

67

Issue

3

Abstract

Since we(1) had been successful in treating amebiasis with aureomycin it was thought possible that this antibiotic might be useful in other parasitic infestations. It was recalled that many amebicidal preparations are effective against T. vaginalis. Subsequent in vitro studies revealed that aureomycin is likewise trichomonicidal. Therefore, it was decided to investigate the action of the local application of aureomycin into the lower female genital tract in T. vaginalis vaginitis. A powder for vaginal insufflation was prepared by adding aureomycin hydrochloride to powdered talc (U.S.P. Merck). The first 6 patients were treated with talc alone. In each of these cases the vagina was insufflated with 2 g of powdered talc on 2 consecutive days and again on the fourth day. At the end of this period the vaginal secretions were negative for T. vaginalis in all 6 cases. Three days following cessation of therapy, the vagina contained T. vaginalis in 5 of the 6 cases. In the sixth patient vaginal secretions did not become positive until the eighth day. The leukorrhea and vaginal inflammation had persisted. Aureomycin in dosages of 2 grams a day for 7 days by mouth has been ineffective in the treatment of this condition. Through the cooperation of the Medical, Gynecological, and Obstetrical Services of the John Gaston Hospital 54 case of T. vaginalis vaginitis were obtained for treatment. Twelve of these patients were pregnant and were referred for treatment by the Obstetrical Service. The diagnosis in each case was established by the demonstration of the organism microscopically in the wet-mount preparation. © 1949, Sage Publications. All rights reserved.

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