The Preparation and Biological Activity of Alpha Estradiol-Sensitized Collodion Particles.

UTHSC Affiliation

College of Medicine

Document Type

Article

Publication Date

1-1-1950

Publication Title

Proceedings of the Society for Experimental Biology and Medicine

Volume

74

Issue

2

Abstract

Crystalline alpha estradiol may be dissolved in acetone solutions of collodion and the steroid incorporated in or on the collodion particles, prepared in the usual manner. Such particles are biologically active as shown by the onset of a cornified vaginal smear in spayed or immature mice and rats. Furthermore, the hormone stimulation appears to persist for prolonged periods, presumably due to the slow elution of the alpha estradiol from the collodion particle. The alpha estradiol-sensitized collodion particles were active after a storage period of four and one half months in the refrigerator. This was established by the onset of cornified cells in spayed rats. © 1950, SAGE Publications. All rights reserved.

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