Electrolytes and plasma expanders - The effect of large dextran infusions on the plasma and erythrocyte sodium, potassium and chloride in the post-hemorrhaged dog

UTHSC Affiliation

College of Medicine

Document Type

Article

Publication Date

11-1-1958

Publication Title

Zeitschrift für die gesamte experimentelle Medizin

Volume

130

Issue

5

Abstract

1. Two series of animals were studied after a rapid hemorrhage of 3.6% of body weight and to a mean blood pressure of less than 70 mm Hg. 2. In the first series of 16 dogs, the animals were replaced immediately after the measured hemorrhage with an equal volume of 6% dextran carried in Gey's solution. 9% saline, or 5% glucose. In the second series of 12 animals the animals were replaced with similar solutions but replacement was made an hour after the hemorrhage. 3. Blood samples were collected at intervals and analyzed for plasma sodium, potassium, and chloride and red cell sodium, potassium and chloride. 4. Less deviation from the control electrolyte values was observed after infusion of dextran in Gey's than after the infusion of either of the other carrier solutions. 5. The replacement with any of these solutions in no instance altered electrolyte concentrations to what might be considered pathological limits. 6. The survival statistics strikingly indicated that the functional capabilities of Gey's solution are much greater than saline or glucose solutions. 7. It is recommended that balanced salt solutions be used as the carrier media for dextran. © 1958 Springer-Verlag.

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