Bromsulfalein Retention Resulting from Liver Damage by a Carbon-Free Filtrate of India Ink
Document Type
Article
Publication Date
1-1-1954
Publication Title
Proceedings of the Society for Experimental Biology and Medicine
Volume
86
Issue
3
Abstract
The administration of a gelatin-stabilized carbon suspension did not affect bromsulfalein (BSP) clearance in dogs. However, a carbon-free nitrate of Higgins India ink markedly inhibited BSP uptake and effected the release of previously stored BSP from the liver. It appears that the effect of India ink on BSP excretion is not due to reticuloendothelial blockade but rather to a toxic effect of some soluble component of the ink on the liver. It is suggested that in dogs BSP clearance is not a suitable index of Kupffer cell activity. © 1954, SAGE Publications. All rights reserved.
Recommended Citation
Zilversmit, D.,
&
Shore, M.
(1954).
Bromsulfalein Retention Resulting from Liver Damage by a Carbon-Free Filtrate of India Ink.
Proceedings of the Society for Experimental Biology and Medicine,
86(3).
http://doi.org/10.3181/00379727-86-21125
Retrieved from: https://dc.uthsc.edu/fac_pubs/313