Gastric Iodide and chloride Clearances in Dogs

Document Type

Article

Publication Date

1-1-1956

Publication Title

Proceedings of the Society for Experimental Biology and Medicine

Volume

93

Issue

3

Abstract

Iodide and chloride clearances were determined in anesthetized and unanesthetized dogs. The control gastric iodide clearance was 10-50 times greater than the chloride clearance. The iodide clearance could be 95% suppressed by anions known to block the thyroid iodide trap but chloride clearance was practically unchanged. In the presence of the blocking agent, gastric iodide and chloride clearances were similar. These data suggest at least 2 mechanisms for gastric secretion of iodide: (a) a specific iodide secretory system and (b) a non-specific mechanism in common with chloride secretion which continues to function after blockade of (a). © 1956, Sage Publications. All rights reserved.

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