A pharmacodynamic study of the anthelmintic properties of two oils of Chenopodium

UTHSC Affiliation

College of Medicine

Document Type

Article

Publication Date

3-1-1925

Publication Title

The Journal of Laboratory and Clinical Medicine

Volume

10

Issue

6

Abstract

In Table I there are twenty-four dogs with a total of 267 ascarides; an average of 11+ per dog. Of these worms the treatment with the Western oil of Chenopodium removed 263. The treatment was, therefore, 98.50 per cent effective against ascarides, a value extremely close to the mathematical average efficacy in Note 1, Table I. There are eighteen dogs in Table II with a total of 161 ascarides; an average of 9 - per dog. The treatment with the wild Western oil of Chenopodium removed 155 worms, and was, therefore, 96.27 per cent effective, which is a little less than the mathematical average efficacy in Note 1, Table II. Table III shows twenty dogs with a total of 192 ascarides; an average of 9.6 per dog. The Maryland Oil of Chenopodium treatment removed 188 of the parasites, and was consequently 97.91 per cent effective, a small fraction less than the mathematical average efficacy in Note 1, Table III. The foregoing figures are tabulated in Table IV. {A table is presented}. The average efficacy of the three samples of oil was, therefore, 97.56 per cent. Examination of the digestive tracts of the animals showed a slight degree of inflammation in three dogs of each of the three series, or a total of nine animals out of sixty-two. This small percentage (14.5 per cent) and the very mild degree of inflammation found indicates that this possible phase of the action of the oils of Chenopodium, in the dosage employed, may be disregarded in the cases of all three oils unless the animal already shows a gastroenteritis. It is interesting to note that practically all the cases showing inflammation were among the heavier dogs which had received a larger dose of the oil. The reader is referred to Hall's study29 of the lesions due to agents used in killing experimental dogs in anthelmintic investigations. © 1924.

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