Effects of Aminopterin and Estrogen on Phosphoprotein Phosphatase of Rat Uterus

Document Type

Article

Publication Date

1-1-1957

Publication Title

Proceedings of the Society for Experimental Biology and Medicine

Volume

95

Issue

2

Abstract

Total phosphoprotein phosphatase activity of rat uterus increases in response to estrogen as uterine weight increases, but activity/g fresh tissue does not change appreciably. Aminopterin administered simultaneously with estrogen inhibits the increase in total activity/uterus as it inhibits uterine weight increase. The changes in enzyme activity could not be correlated with changes in uterine phosphoprotein and the possible existence of a phosphatase inhibitor was discussed. © 1957, SAGE Publications. All rights reserved.

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