Influence of Low Dose of 2-Acetylaminofluorene on Liver Tumorigenesis in Mice
Document Type
Article
Publication Date
1-1-1959
Publication Title
Proceedings of the Society for Experimental Biology and Medicine
Volume
101
Issue
4
Abstract
Administration by stomach tube of a suspension containing 2-acetylaminofluorene to suckling albino mice was followed by development of high incidence of hepatomas in males (60%) but not in females (1%). A similarly low incidence of hepatomas (0%-4%) was observed in untreated mice from same strain or mice treated with suspension alone. The low dose of 2-acetylaminofluorene represents smallest quantity of this compound effective to date in liver tumorigenesis. Also, results indicate that suckling male mouse is especially susceptible to hepatoma induction with 2-acetylaminofluorene. © 1959, SAGE Publications. All rights reserved.
Recommended Citation
Klein, M.
(1959).
Influence of Low Dose of 2-Acetylaminofluorene on Liver Tumorigenesis in Mice.
Proceedings of the Society for Experimental Biology and Medicine,
101(4).
http://doi.org/10.3181/00379727-101-25043
Retrieved from: https://dc.uthsc.edu/fac_pubs/388