The renal lesion in hyperparathyroidism

UTHSC Affiliation

College of Medicine

Document Type

Article

Publication Date

1-1-1939

Publication Title

Endocrinology

Volume

24

Issue

3

Abstract

Chronic hyperparathyrofdism is associated with distinctive microscopic changes in the kidney. The characteristic features are interstitial fibrosis, calcification and infiltration by lymphocytes and plasma cells, cystic tubular dilatation, thickening and sometimes calcification of tubular basement membranes, and relative absence of active glomerulitis or involvement of tubular epithelial cells. In individual cases this picture may be varied by calculus formation and superimposed ascending infection. The interstitial calcium deposition is mainly peritubular and is preceded by damage inflicted on kidney tissue, and which would seem to be one of the factors determining the localisation of the mineral deposit. Further damage results from interference with tubular function and tubular obstruction. The distinctive clinical features in some of these cases may be related to the relative absence of glomenilitis and vascular changes. The microscopic appearance of the kidney may be distinguished from that of acute hyperparathyroidism as produced experimentally in animals (13). © 1939 by The Endocrine Society.

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