Severe neurological manifestations in four children receiving compazine (prochlorperazine)
UTHSC Affiliation
College of Medicine
Document Type
Article
Publication Date
1-1-1958
Publication Title
The Journal of Pediatrics
Volume
53
Issue
2
Abstract
Summary1.Severe neurological manifestations in four children receiving Compazine are reported.2.These dramatic reactions consist of recurrent episodes of marked drowsiness and lethargy, oculogyric crises, retraction of the neck, at times with torticollis, trismus, opisthotonos, sometimes flexor rigidity, and hyperreflexia.3.The amount of the drug given was clearly excessive in two cases and unknown in one, in which the child took the medication accidentally. However, the most severe reaction of all occurred in the child who received the usually recommended dosage.4.All children recovered rather rapidly without any specific treatment being required and no aftereffects were observed over the brief period of one month. © 1958 The C. V. Mosby Company.
Recommended Citation
Jabbour, J.,
Sheffield, J.,
&
Montalvo, J.
(1958).
Severe neurological manifestations in four children receiving compazine (prochlorperazine).
The Journal of Pediatrics,
53(2).
http://doi.org/10.1016/S0022-3476(58)80167-5
Retrieved from: https://dc.uthsc.edu/fac_pubs/228