Theses/Dissertations from 2023
TCF4 Is a Key Mediator of Cell Identity and Oncogenesis in Neuroblastoma, Nour Aljouda
Androgen Receptor: A Complex Therapeutic Target in Breast Cancer, Sarah Tinuade Asemota
The NTF2L Domain Is a Date Hub That Interacts with SLiMs to Regulate Assembly of Stress Granules, Jinjun Wu
Theses/Dissertations from 2022
Ribonucleotide Reductase Subunit Switching in Hepatoblastoma Drug Response and Relapse, Anthony Brown
The Role and Immunogenicity of CBFA2T3-GLIS2 in Pediatric Acute Megakaryoblastic Leukemia, Elizabeth A. Garfinkle
Exploring Risk Factors of Alzheimer’s Disease Using Mouse Models, Xian Han
Developing Targeted Therapies for T-cell Acute Lymphoblastic Leukemia, Jianzhong Hu
OTULIN's Novel Regulatory Mechanisms in Genotoxic and Inflammatory NF-kB Signaling, Mingqi Li
Mitophagy-Mediated Regulation of ROS Homeostasis During HSC Activation Contributes to Cell Fate, Amber Lynne Smith
Theses/Dissertations from 2021
Investigating the Role of ZNF384 Rearrangements in Acute Leukemia, Kirsten Dickerson
The Molecular Mechanisms of Estrogen Receptor α on Two Single Nucleotide Polymorphisms to Regulate WNT Signaling in Osteoblasts, Sarocha Suthon
Genetic Mechanisms of Transcriptional Regulation in Childhood Acute Lymphoblastic Leukemia, Xujie Zhao
Theses/Dissertations from 2020
Investigation of a Novel Mitophagy Regulatory Pathway and Chemical Inducer, Jane E. Craig
The Characterization of Hematopoiesis in Murine Fetal Bone Marrow, Trent Daniel Hall
Genomic Instability and the Oncohistone H3K27M Drive Gliomagenesis in a Murine Model, Lee J. Pribyl
Mechanisms of BAK Activation in the Initiation of Mitochondrial Apoptosis, Geetika Singh
Characterization of Genome-Wide Binding of NUCLEAR-FACTOR I-X in Hematopoietic Progenitor Cells, Megan J. Walker
Arid1a Haploinsufficiency Initiates Neural Crest Transformation in a Mouse Model of Mycn-driven Neuroblastoma, Kirby A. Wallace
Selective Targeting of CYP3A5 Through Chemical and Genetic Approaches, William C. Wright
Eukaryotic Initiation Factor 5A2 (EIF5A2) Contributes to Ovarian Tumor Growth and Metastasis, Guannan Zhao
Theses/Dissertations from 2019
Regulation of CYP3A5 in Pancreatic Ductal Adenocarcinoma, Jessica D. Hoyer
Study of Natural Killer Cells and Their Therapeutic Role in Pediatric Cancer, Hong Ha Rosa Nguyen
Delineating the Mechanisms of Misfolded Endoplasmic Reticulum (ER) Luminal Protein Retrotranslocation for ER-Associated Degradation, Christina Oikonomou
Theses/Dissertations from 2018
Understanding the Impact of BCRP and PGP Efflux Transporters on the Disposition of Their Endogenous, Xenobiotic and Dietary Substrates, Samit Ganguly
Role of SMARCE1 and BHLHE40 in Breast Cancer Metastasis, Aarti Sethuraman
Roles of Cytosolic Nucleic Acid Sensors in Cancer and Infection, Qifan Zhu
Theses/Dissertations from 2017
Investigating the Role of Dispatched in Hedgehog Ligand Transport and Delivery, William Bodeen
Metabolic Regulation of Cellular Signaling, Rashid John Darbandi
Using S. pombe to Study the Biological Roles of the Histone Deacetylases Sir2 and Clr3 and the DEAD-Box RNA Helicase Ded1, Brandon Ray Lowe
Revealing a Non-canonical Role of Anti-apoptotic MCL-1 in Early Embryonic Development, Xue Yang
Theses/Dissertations from 2016
The Nucleolar Protein Nucleophosmin Undergoes Liquid-Liquid Phase Separation with Arginine-Rich Nucleolar Proteins through Weak, Multivalent Electrostatic Interactions, Jaclyn Alicia Cika
Novel Oncogenic Drivers in Pediatric Gliomagenesis, Alexander K. Diaz
The Roles of Nuclear Receptor NR4A1 in Cancer Cell Proliferation and Skeletal Muscle Differentiation, Alexa Farmer
Environmental Signaling through the Target of Rapamycin Complex 1 (TORC1) and the Regulation of Epigenetic Mechanisms, Jason J. Workman
Theses/Dissertations from 2015
Integration of ATM, ATR, and DNA-PKcs Signaling Maintains Genome Integrity During Neurogenesis, Vanessa D. Enriquez-Rios
Reprogramming to Pluripotency Using Small Molecule Compounds, Brittany E. Greenberg
Theses/Dissertations from 2014
Molecular Characterization of Glioblastoma Cancer Stem Cells, Jo Meagan Garner
Functional and Genetic Analysis of Choroid Plexus Development in Zebrafish, Hannah Elizabeth Henson
Characterization of Cre Mouse Models to Target CNS Barriers for Generating Conditional Knockouts of ABC Transporters, Rachel L. Scheib
Theses/Dissertations from 2013
Development and Characterization of a Recombinant Vesicular Stomatitis Virus (rVSV) for the Treatment of Glioblastoma, Erika A. Dillard
Functional Study of Hemogen Knockout Mouse Model, Peng Gao
Identification of Novel HIF1A Target Genes That Regulate Tumor Progression and Metastasis, Danielle L. Peacock
The Protumorigenic Role of Caspase-8 in Neuroblastoma, Devin Drew Twitchell
Theses/Dissertations from 2012
Inhibition of Breast Cancer Angiogenesis and Metastasis ay Targeting Hypoxia-Inducible Factor-1α, Chikezie O. Madu
Anti-apoptotic MCL-1 Localizes to the Mitochondrial Matrix and Couples Mitochondrial Fusion to Respiration, Rhonda Perciavalle
Contribution of the Unfolded Protein Response to VEGF Expression, Ethel Rose Pereira
The Role of the YXXΦ Motif in CD82 Trafficking and Function, Mekel Marie Richardson
The Role of BiP Nucleotide Exchange Factor Sil1 in Immunoglobulin Biosynthesis, Tyler Sanford
Discovery of Dihydroartemisinin and Dasatinib Drug Combination to Cure Pooroutcome BCR-ABL+ Acute Lymphoblastic Leukemia, Harpreet Singh
Theses/Dissertations from 2011
Insights into p53-Dependent Apoptotic Signaling and Cell Fate vis-a-vis Functional Cooperation among BCL-xL, Cytoplasmic p53, and PUMA, John C. Fisher
The Treatment of Breast Cancer Tumor Growth and Metastasis With an Anti-MMP9 DNAzyme, Miranda A. Hallett
Characterization of the Key Mouse Cochlear Developmental Genes for Auditory Hair Cell Regeneration, Zhiyong Liu
Pten Function in Postnatal Brain Development and Tumorigenesis, Guo Zhu
Theses/Dissertations from 2010
The Use of Preclinical Models to Improve the Treatment of Retinoblastoma, Katie Marie Nemeth
The Role of Pkd1 in Mouse Inner Ear Hair Cells, Katherine Ann Steigelman
CD151 Reinforces Vascular Stability by Balancing Endothelial Cell Adhesion and Cytoskeletal Tension, Feng Zhang
Theses/Dissertations from 2009
Pax5 Haploinsufficiency Cooperates with BCR-ABL1 to Induce Acute Lymphoblastic Leukemia, Christopher B. Miller