Theses/Dissertations from 2023
Targeting Prostaglandin E2 Receptor EP2 for Treatment of High-Risk Neuroblastoma, Ruida Hou
Transmission Competence of B. burgdorferi Infected Ixodes Ticks and Development of an OspC-Based Lyme Disease Vaccine, Samanta Kamalika
Physiologically-Based Pharmacokinetic (PBPK) Modeling for the Preclinical Development of Spectinamide Antibiotics, Keyur R. Parmar
PKPD-Model Based Preclinical Characterization of the Activity of Spectinamide 1599 Against Mycobacterial Subpopulations. and the Identification of Potential Partners for Combination Therapy, Zaid Hanif Temrikar
Studies on the Leukocyte-Associated Ig-Like Inhibitory Receptor-1 Signaling Pathway in T Lymphocytes, Chidi Zacheaus
Theses/Dissertations from 2022
Targeting Myeloid Protein Kinase C Signaling to Overcome Immune Suppression and Improve Immunotherapy in Cancer, Mehdi Chaib
Targeting Protein Degradation to Uncover Novel Oncoprotein Drivers of Acute Leukemia, Fatemeh Keramatnia
Host-Pathogen Interactions During Leptospirosis in Male C3H/HeJ Mice, Advait Bhaskar Shetty
Computer-Aided Drug Discovery for Helicobacter pylori, Nicole Ann Vita
Theses/Dissertations from 2021
Antibiotic Tolerance and Heteroresistance: Associated Fitness Costs and Potential in Evading Antibiotic Killing, Tina H. Dao
MUC13 Enhances Colorectal Cancer Metastasis, Kyle Doxtater
Combating HIV-1 by Targeting Drug Efflux Transporters on the Macrophage Reservoir, Ying Mu
Theses/Dissertations from 2020
Novel Paclitaxel Nanoparticles for Enhanced Therapeutic Effects in Breast Cancer, Pallabita Chowdhury
Tobacco/HIV-1-Induced Myeloid Cell-Derived Extracellular Vesicles in HIV-1 Pathogenesis, Sanjana Haque
Design, Development and Evaluation of Dual Drug Nanomedicine for Non-Small Cell Lung Cancer, Elham Hatami
MUC13 Modulated Nanomechanical and Biophysical Responses in Pancreatic Cancer Cells, Andrew E. Massey
Characterization of Novel CB2 Agonist SMM-295 and Its Effects in Ischemia/Reperfusion Injury, Jeffrey D. Pressly
Development of Novel Therapeutic Strategies for Pancreatic Cancer Treatment, Saini Setua
Model-Based Dose-Exposure-Response Assessment for Lead and Backup Spectinamide in a Mouse Model of Tuberculosis, Santosh Janardan Wagh
Theses/Dissertations from 2019
An Update on Pharmaceutical Strategies for Oral Delivery of Therapeutic Peptides and Proteins, Nirnoy Dan
Investigation of Narrow Spectrum Targets in Antibacterial Drug Discovery, Jesse Jones
Molecular Mechanisms of Metabolic Reprogramming in Pancreatic Cancer, Sonam Kumari
The Discovery and Development of Thienopyrimidines as Inhibitors of Helicobacter pylori, Alex Kagabo Mugengana
Injectable Systems for Long-Lasting Insulin Therapy, Kumar Kulldeep Niloy
An Investigation into Clinically Relevant Determinants of Azole Resistance in Candida albicans, Andrew T. Nishimoto
Identification of Novel CYP2E1 Inhibitor to Investigate Cellular and Exosomal CYP2E1-Mediated Toxicity, Mohammad Arifur Rahman
Theses/Dissertations from 2018
Targeting the Colchicine Binding Site on Tubulin to Overcome Multidrug Resistance and Anticancer Efficacy of Selective Survivin Inhibitors, Kinsle E. Arnst
Rheological Studies of Injectable Thermoresponsive Biodegradable Hydrogels and Porcine Ocular Tissues, Chandana Reddy Damera
Molecular Response of Retinal Pigment Epithelial Cells to Oxidized Lipoproteins: Global and Targeted Studies, Diwa Koirala
Development of Multiple Microemulsion Eye Drops for Sustained Release of New Glaucoma Drug, Doaa Nabih Ahmed Maria
Effect of Comorbidities on HIV-1 Pathogenesis in Monocytic Cells, Sabina Ranjit
Genetic Exploration of Hereditary Immune Diseases, Cheng Tian
Novel Determinants That Influence Azole Susceptibility in Candida glabrata and Candida albicans, Sarah Garland Whaley
Somatic Mutation Detection in Leukemia-Derived Circulating DNA: Utility in Monitoring Clonal Dynamics and Disease Response in Pediatric Acute Lymphoblastic Leukemia, Sarah Hisham Abdelaziz Youssef
Theses/Dissertations from 2017
Cannabinoid Receptor 2 (CB2) Ligands Downregulate Pro-Inflammatory Markers in Stimulated Primary Human Periodontal Ligament Fibroblasts (hPDLFs), Ammaar Hasan Abidi
Therapeutic Effects of Ormeloxifene in Cervical Cancer Carcinogenesis, Neeraj Chauhan
Biodegradable Polymeric Biomaterials in Different Forms for Long-acting Contraception and Drug Delivery to the Eye and Brain, Dileep Reddy Janagam
Synthesis of 20S-Hydroxyvitamin D3 Analogs and Their 1α-Hydroxyl Derivatives as Potent Anti-inflammatory Agents, Zongtao Lin
The Development of Methods to Account for Physiologic Dynamic Changes and Their Effects on the Pharmacokinetics of Therapeutic Monoclonal Antibodies and other Therapeutics, Josiah Thomas Ryman
Discovery of Natural Product-based Antimycobacterial Agents Effective against Non-replicating Bacilli, Shajila Siricilla
Design, Synthesis, and Evaluation of Novel Positron Emission Tomography Radiotracers, Christopher Philip Surdock
Age-Associated Expression Patterns of OATP 1B1 and OATP 1B3 and Their Effect on the Disposition of Fexofenadine, Margaret Mary Thomson
Theses/Dissertations from 2016
REGULATION OF CANCER METASTASIS BY PROTEIN KINASE D1: A GLOBAL REGULATORY CASCADE, Aditya Ganju
Antibiotic Drug Discovery with an Eye Towards Overcoming Drug Resistance, Daniel Towner Hoagland
Validation of ACTOne CB1 and CB2 Assays, Subsequent Characterization of SMM-189, and Development and Characterization of New CB2 Inverse Agonists, Chaela Sickbert Presley
Discoveries of Targets and Novel Agents for the Treatment of Ischemic Retinopathy and Neovascular Disease, Jordan Javad Toutounchian
Theses/Dissertations from 2015
Development and evaluation of amphotericin B Loaded iron oxide nanoparticles for targeted drug delivery to systemic fungal infections, Pavan Balabathula
Functional Activity and Switching of Novel Cannabinergic Ligands, Bret Alan Koertge
Challenges in the Pharmacokinetics of Therapeutic Proteins, Wararat Limothai
Design, Development and Evaluation of Erlotinib-Loaded Hybrid Nanoparticles for Targeted Drug Delivery to NonSmall Cell Lung Cancer, Bivash Mandal
Design, Development, Characterization and Testing of CD22 Targeted Long Circulating Liposomal Drug Delivery Systems for B Cell Malignancies, Nivesh Kumar Mittal
Optimization of Lead Spectinamide Compounds as Novel Anti-tuberculosis Agents with a Pharmacometric Approach, Ashit Rasendu Trivedi
Theses/Dissertations from 2014
Glioma: A Tale of Corticosteroids, Thiopurines and Proposed Novel AntiGlioma Small Molecules, Amira Ahmed
Computer-Aided Drug Design and Discovery, Screening and Synthesis of Small Molecule Inhibitors of Nucleoside Transporters, Hilaire Colleen Playa
Development of a Novel Vaccine Adjuvant System Utilizing an In Situ Implant System to Modified Release, Qiuye Zhang
Theses/Dissertations from 2013
A Series of Pharmaceutical Technology Concepts Applied to Pediatric Formulations, Hao Lou
Gene Therapy and Stem Cell Therapy to Improve the Outcome of Human Islet Transplantation, Hao Wu
Theses/Dissertations from 2012
Nanotherapies for Treating Prostate Cancer, Michael Danquah
Effect of Compression Force on Agglomeration of Micronized Active Pharmaceutical Ingredients: Techniques to Prevent API Agglomeration During Compression, Suresh Potharaju
High Resolution Mass Spectrometry (HRMS) Based Investigation of Small Molecule, Bioactive Secondary Metabolites as Probes in the Examination of Bacterial Resistance and Virulence, Jerrod Stephen Scarborough
Investigations of Pharmacokinetic Challenges in Premature Infants, Yi Zhang
Development of Co-processed Plasticized Cellulose Acetate for Sustained Release Matrix Tablets, Yinqi Zhou
Theses/Dissertations from 2011
A Novel Shear Thinning and Thixotropic Plga Micro Particulate Suspension System for Controlled Drug Delivery, Sonia Bedi
The Design and Synthesis of Autotaxin Inhibitors and Analogs of Lysophosphatidic Acid, Renuka Niranjan Gupte
Synthesis and Computational Studies on Hiv-1 Integrase Inhibitors, Horrick Sharma
Pharmacokinetic and Pharmacodynamic Studies of a Novel Spectinamide Series of Antituberculosis Agents, V. N. R. Pavan Kumar Vaddady
Development and Evaluation of Nano‑scale Systems for Targeted Delivery to Treat Liver Fibrosis, Ningning Yang
Preclinical Pharmacology of the MDM2 Antagonist Nutlin-3a, Fan Zhang
Theses/Dissertations from 2010
The Design and Synthesis of Novel Antimicrobial Agents for Use in the Battle Against Bacterial Resistance, Joshua Randal Brown
Transcriptional Regulation of Azole Antifungal Resistance and Tolerance in Candida Glabrata, Kelly E. Caudle
Population Pharmacokinetics of Therapeutic Monoclonal Antibodies: Examples and Estimation Method Performance Differences, Nathanael Le Dirks
Synthesis of Novel Cannabinoid Ligands and Their Use as Anti-Glioma and Anti-Inflammatory Agents, Steven Neal Gurley
Development and Evaluation of Paclitaxel-Loaded Liposomal Formulations for Targeted Drug Delivery to Breast Cancer, Vinayagam Kannan
Therapeutic Gene Delivery to Human Pancreatic Islets for Treatment of Diabetes and the Effect of TFO on Liver Fibrosis Induced by Bile Duct Ligation, Ravikiran Panakanti
Development and Evaluation of Therapeutics in the Setting of Radiation Injury, Karin Emmons Thompson
TDiscovery and Development of Novel Therapeutic Agents for Advanced Melanoma, Zhao Wang
Discovery of Quinic Acid Derivatives as Oral Anti-inflammatory Agents, Kui Zeng
Design of Lipid and Polymeric Carriers for Nucleic Acid Delivery, Lin Zhu
Theses/Dissertations from 2009
A Pharmacokinetics and Pharmacodynamics (PK/PD) Guided Approach to Lead Optimization of Nitrofuranylamide Anti-Tuberculosis Agents, Nageshwar Rao Budha
Application of Different Bioanalytical Workflows for Proteomics of Prostate Cancer, Li Chen
Targeted Delivery of Surface Modified Nanoparticles: Modulation of Inflammation for Acute Lung Injury, Hari R. Desu
The Use of Spectroscopic Techniques in the Characterization of Mycobacterial Metabolites, Engy Abdelhameed Mahrous
Theses/Dissertations from 2008
Controlled Release of Insulin and Modified Insulin from a Novel Injectable Biodegradable Gel, Om Anand
Structure-Activity Relationship and Mechanistic Studies on the Chemopreventive Activity of Dipyridamole and Its Analogues, Ja’Wanda Shavon Grant
Structure- and Ligand-Based Design of Novel Antimicrobial Agents, Kirk Edward Hevener
Flavonoids and Related Compounds as Nucleoside Transporter Inhibitors, Surekha Ravaji Pimple
Synthesis and Evaluation of Tetramic Acids as Antimicrobial Agents, Jason B. Wilson
Theses/Dissertations from 2007
Development and Evaluation of Brain Tumor Targeted Liposome Delivery System for Paclitaxel, Murali Krishna Divi