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Theses/Dissertations from 2024

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Targeting Coenzyme A Biosynthesis for Antifungal Development., Jessica Regan

Theses/Dissertations from 2023

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Discovery of Inhibitors of Inhibitors of Apoptosis Proteins and Novel Tubulin Polymerization Inhibitors as Potential Anticancer Agents, Najah Ghazi Albadari

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Targeting Prostaglandin E2 Receptor EP2 for Treatment of High-Risk Neuroblastoma, Ruida Hou

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Transmission Competence of B. burgdorferi Infected Ixodes Ticks and Development of an OspC-Based Lyme Disease Vaccine, Samanta Kamalika

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Design and Synthesis of Novel Small Molecule Drugs for the Treatment of Cancer and Osteoporosis, Hanxuan Li

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The Therapeutic Role of LM11A-31 (a p75NTR Modulator) in the Outcome of Ischemic Stroke and HIV-1 Pathogenesis, Golnoush Mirzahosseini

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Physiologically-Based Pharmacokinetic (PBPK) Modeling for the Preclinical Development of Spectinamide Antibiotics, Keyur R. Parmar

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PKPD-Model Based Preclinical Characterization of the Activity of Spectinamide 1599 Against Mycobacterial Subpopulations. and the Identification of Potential Partners for Combination Therapy, Zaid Hanif Temrikar

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Studies on the Leukocyte-Associated Ig-Like Inhibitory Receptor-1 Signaling Pathway in T Lymphocytes, Chidi Zacheaus

Theses/Dissertations from 2022

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Targeting Myeloid Protein Kinase C Signaling to Overcome Immune Suppression and Improve Immunotherapy in Cancer, Mehdi Chaib

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Targeting Protein Degradation to Uncover Novel Oncoprotein Drivers of Acute Leukemia, Fatemeh Keramatnia

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Host-Pathogen Interactions During Leptospirosis in Male C3H/HeJ Mice, Advait Bhaskar Shetty

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Computer-Aided Drug Discovery for Helicobacter pylori, Nicole Ann Vita

Theses/Dissertations from 2021

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Antibiotic Tolerance and Heteroresistance: Associated Fitness Costs and Potential in Evading Antibiotic Killing, Tina H. Dao

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MUC13 Enhances Colorectal Cancer Metastasis, Kyle Doxtater

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Combating HIV-1 by Targeting Drug Efflux Transporters on the Macrophage Reservoir, Ying Mu

Theses/Dissertations from 2020

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Development and Characterization of Selective CB2R Inverse Agonists as a Novel Anti-Inflammatory Therapy for Neuroinflammation – Mechanisms of Action in Murine and Human Microglia Models Provide Valuable Insights into Their Therapeutic Potential, Sahar Saleh Alghamdi

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Novel Paclitaxel Nanoparticles for Enhanced Therapeutic Effects in Breast Cancer, Pallabita Chowdhury

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VERU-111 as an Oral Tubulin Inhibitor Suppressing Triple-Negative Breast Cancer and Evaluation of Novel Tubulin Inhibitors for Cancer Therapy, Shanshan Deng

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A Novel Elvitegravir Nanoformulation for Drug Delivery Across the Blood-Brain Barrier to Suppress HIV-1 in Macrophages and Microglia, Yuqing Gong

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Tobacco/HIV-1-Induced Myeloid Cell-Derived Extracellular Vesicles in HIV-1 Pathogenesis, Sanjana Haque

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Design, Development and Evaluation of Dual Drug Nanomedicine for Non-Small Cell Lung Cancer, Elham Hatami

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MUC13 Modulated Nanomechanical and Biophysical Responses in Pancreatic Cancer Cells, Andrew E. Massey

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Characterization of Novel CB2 Agonist SMM-295 and Its Effects in Ischemia/Reperfusion Injury, Jeffrey D. Pressly

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Development of Novel Therapeutic Strategies for Pancreatic Cancer Treatment, Saini Setua

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Model-Based Dose-Exposure-Response Assessment for Lead and Backup Spectinamide in a Mouse Model of Tuberculosis, Santosh Janardan Wagh

Theses/Dissertations from 2019

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An Update on Pharmaceutical Strategies for Oral Delivery of Therapeutic Peptides and Proteins, Nirnoy Dan

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Investigation of Narrow Spectrum Targets in Antibacterial Drug Discovery, Jesse Jones

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Molecular Mechanisms of Metabolic Reprogramming in Pancreatic Cancer, Sonam Kumari

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The Discovery and Development of Thienopyrimidines as Inhibitors of Helicobacter pylori, Alex Kagabo Mugengana

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Injectable Systems for Long-Lasting Insulin Therapy, Kumar Kulldeep Niloy

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An Investigation into Clinically Relevant Determinants of Azole Resistance in Candida albicans, Andrew T. Nishimoto

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Identification of Novel CYP2E1 Inhibitor to Investigate Cellular and Exosomal CYP2E1-Mediated Toxicity, Mohammad Arifur Rahman

Theses/Dissertations from 2018

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Targeting the Colchicine Binding Site on Tubulin to Overcome Multidrug Resistance and Anticancer Efficacy of Selective Survivin Inhibitors, Kinsle E. Arnst

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Rheological Studies of Injectable Thermoresponsive Biodegradable Hydrogels and Porcine Ocular Tissues, Chandana Reddy Damera

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Molecular Response of Retinal Pigment Epithelial Cells to Oxidized Lipoproteins: Global and Targeted Studies, Diwa Koirala

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Development of Multiple Microemulsion Eye Drops for Sustained Release of New Glaucoma Drug, Doaa Nabih Ahmed Maria

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Effect of Comorbidities on HIV-1 Pathogenesis in Monocytic Cells, Sabina Ranjit

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Genetic Exploration of Hereditary Immune Diseases, Cheng Tian

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Novel Determinants That Influence Azole Susceptibility in Candida glabrata and Candida albicans, Sarah Garland Whaley

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Somatic Mutation Detection in Leukemia-Derived Circulating DNA: Utility in Monitoring Clonal Dynamics and Disease Response in Pediatric Acute Lymphoblastic Leukemia, Sarah Hisham Abdelaziz Youssef

Theses/Dissertations from 2017

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Cannabinoid Receptor 2 (CB2) Ligands Downregulate Pro-Inflammatory Markers in Stimulated Primary Human Periodontal Ligament Fibroblasts (hPDLFs), Ammaar Hasan Abidi

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Therapeutic Effects of Ormeloxifene in Cervical Cancer Carcinogenesis, Neeraj Chauhan

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Biodegradable Polymeric Biomaterials in Different Forms for Long-acting Contraception and Drug Delivery to the Eye and Brain, Dileep Reddy Janagam

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Synthesis of 20S-Hydroxyvitamin D3 Analogs and Their 1α-Hydroxyl Derivatives as Potent Anti-inflammatory Agents, Zongtao Lin

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Translational Pharmacokinetic-Pharmacodynamic Modeling and Simulation in the Development of Spectinamides, a Novel Class of Anti-Tuberculosis Agents, Chetan Rathi

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The Development of Methods to Account for Physiologic Dynamic Changes and Their Effects on the Pharmacokinetics of Therapeutic Monoclonal Antibodies and other Therapeutics, Josiah Thomas Ryman

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Discovery of Natural Product-based Antimycobacterial Agents Effective against Non-replicating Bacilli, Shajila Siricilla

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Design, Synthesis, and Evaluation of Novel Positron Emission Tomography Radiotracers, Christopher Philip Surdock

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Age-Associated Expression Patterns of OATP 1B1 and OATP 1B3 and Their Effect on the Disposition of Fexofenadine, Margaret Mary Thomson

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Discovery of Novel Tubulin Inhibitors and Selective Survivin Inhibitors for Advanced Melanoma and Total Synthesis of Bioactive 20S-hydroxyvitamin D3, Qinghui Wang

Theses/Dissertations from 2016

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REGULATION OF CANCER METASTASIS BY PROTEIN KINASE D1: A GLOBAL REGULATORY CASCADE, Aditya Ganju

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Antibiotic Drug Discovery with an Eye Towards Overcoming Drug Resistance, Daniel Towner Hoagland

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Validation of ACTOne CB1 and CB2 Assays, Subsequent Characterization of SMM-189, and Development and Characterization of New CB2 Inverse Agonists, Chaela Sickbert Presley

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Discoveries of Targets and Novel Agents for the Treatment of Ischemic Retinopathy and Neovascular Disease, Jordan Javad Toutounchian

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Hit Identification for PKCζ Inhibitors: Structure-Based Optimization, Virtual Screening, and Biological Evaluation, Xiaoxin Wu

Theses/Dissertations from 2015

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Development and evaluation of amphotericin B Loaded iron oxide nanoparticles for targeted drug delivery to systemic fungal infections, Pavan Balabathula

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Functional Activity and Switching of Novel Cannabinergic Ligands, Bret Alan Koertge

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Challenges in the Pharmacokinetics of Therapeutic Proteins, Wararat Limothai

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Design, Development and Evaluation of Erlotinib-Loaded Hybrid Nanoparticles for Targeted Drug Delivery to NonSmall Cell Lung Cancer, Bivash Mandal

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Design, Development, Characterization and Testing of CD22 Targeted Long Circulating Liposomal Drug Delivery Systems for B Cell Malignancies, Nivesh Kumar Mittal

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Optimization of Lead Spectinamide Compounds as Novel Anti-tuberculosis Agents with a Pharmacometric Approach, Ashit Rasendu Trivedi

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Overcoming Acquired Resistance to BRAF Inhibitors by Novel Synergistic Drug Combination and Discovery of Novel Smac Mimetics as Selective Survivin Inhibitors, Jin Wang

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Discovery of Novel Tubulin Polymerization Inhibitors and Survivin Inhibitors as Potential Anticancer Agents, Min Xiao

Theses/Dissertations from 2014

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Glioma: A Tale of Corticosteroids, Thiopurines and Proposed Novel AntiGlioma Small Molecules, Amira Ahmed

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Computer-Aided Drug Design and Discovery, Screening and Synthesis of Small Molecule Inhibitors of Nucleoside Transporters, Hilaire Colleen Playa

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Development of a Novel Vaccine Adjuvant System Utilizing an In Situ Implant System to Modified Release, Qiuye Zhang

Theses/Dissertations from 2013

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A Series of Pharmaceutical Technology Concepts Applied to Pediatric Formulations, Hao Lou

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Gene Therapy and Stem Cell Therapy to Improve the Outcome of Human Islet Transplantation, Hao Wu

Theses/Dissertations from 2012

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Nanotherapies for Treating Prostate Cancer, Michael Danquah

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Preclinical Study of Potential Antiglioma Novel Tetrahydroisoquinoline Analogs: Pharmacokinetics and Mechanism of Action, Fei Ma

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Effect of Compression Force on Agglomeration of Micronized Active Pharmaceutical Ingredients: Techniques to Prevent API Agglomeration During Compression, Suresh Potharaju

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High Resolution Mass Spectrometry (HRMS) Based Investigation of Small Molecule, Bioactive Secondary Metabolites as Probes in the Examination of Bacterial Resistance and Virulence, Jerrod Stephen Scarborough

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Development of the Sustained Release Analgesic Formulations for Rodents and a Novel In Vitro Model for Parenteral Formulations with the Character of a Level A IVIVC, Jin Xu

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Investigations of Pharmacokinetic Challenges in Premature Infants, Yi Zhang

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Development of Co-processed Plasticized Cellulose Acetate for Sustained Release Matrix Tablets, Yinqi Zhou

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Investigation of Enhancement of Furosemide Solubilization with Cyclodextrins and a Novel Octenyl Succinate Anhydride Starch, Rui Zhu

Theses/Dissertations from 2011

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A Novel Shear Thinning and Thixotropic Plga Micro Particulate Suspension System for Controlled Drug Delivery, Sonia Bedi

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The Design and Synthesis of Autotaxin Inhibitors and Analogs of Lysophosphatidic Acid, Renuka Niranjan Gupte

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RNA Interference for Improving the Outcome of Islet Transplantation and Polymeric Micelle‑based Nanomedicine for Cancer Therapy, Feng Li

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Synthesis and Computational Studies on Hiv-1 Integrase Inhibitors, Horrick Sharma

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Pharmacokinetic and Pharmacodynamic Studies of a Novel Spectinamide Series of Antituberculosis Agents, V. N. R. Pavan Kumar Vaddady

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Development and Evaluation of Nano‑scale Systems for Targeted Delivery to Treat Liver Fibrosis, Ningning Yang

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Preclinical Pharmacology of the MDM2 Antagonist Nutlin-3a, Fan Zhang

Theses/Dissertations from 2010

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The Design and Synthesis of Novel Antimicrobial Agents for Use in the Battle Against Bacterial Resistance, Joshua Randal Brown

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Transcriptional Regulation of Azole Antifungal Resistance and Tolerance in Candida Glabrata, Kelly E. Caudle

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Population Pharmacokinetics of Therapeutic Monoclonal Antibodies: Examples and Estimation Method Performance Differences, Nathanael Le Dirks

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Synthesis of Novel Cannabinoid Ligands and Their Use as Anti-Glioma and Anti-Inflammatory Agents, Steven Neal Gurley

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Development and Evaluation of Paclitaxel-Loaded Liposomal Formulations for Targeted Drug Delivery to Breast Cancer, Vinayagam Kannan

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Therapeutic Gene Delivery to Human Pancreatic Islets for Treatment of Diabetes and the Effect of TFO on Liver Fibrosis Induced by Bile Duct Ligation, Ravikiran Panakanti

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Development and Evaluation of Therapeutics in the Setting of Radiation Injury, Karin Emmons Thompson

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TDiscovery and Development of Novel Therapeutic Agents for Advanced Melanoma, Zhao Wang

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Discovery of Quinic Acid Derivatives as Oral Anti-inflammatory Agents, Kui Zeng

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Design of Lipid and Polymeric Carriers for Nucleic Acid Delivery, Lin Zhu

Theses/Dissertations from 2009

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A Pharmacokinetics and Pharmacodynamics (PK/PD) Guided Approach to Lead Optimization of Nitrofuranylamide Anti-Tuberculosis Agents, Nageshwar Rao Budha

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Application of Different Bioanalytical Workflows for Proteomics of Prostate Cancer, Li Chen

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Targeted Delivery of Surface Modified Nanoparticles: Modulation of Inflammation for Acute Lung Injury, Hari R. Desu

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The Use of Spectroscopic Techniques in the Characterization of Mycobacterial Metabolites, Engy Abdelhameed Mahrous

Theses/Dissertations from 2008

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Controlled Release of Insulin and Modified Insulin from a Novel Injectable Biodegradable Gel, Om Anand

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Structure-Activity Relationship and Mechanistic Studies on the Chemopreventive Activity of Dipyridamole and Its Analogues, Ja’Wanda Shavon Grant