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Theses/Dissertations from 2024

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Loss of the SAC Components SldA Kinase or SldB or in vitro Adaptation to Triazole Produces Aneuploidy Associated with Triazole Heteroresistance in Aspergillus fumigatus, Ashley Nywening

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Regulation of PIEZO Channels by Membrane Lipids, Luis Octavio Romero Garcia

Theses/Dissertations from 2023

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Inhibition of KDM4 with QC6352 to Target High-Risk Neuroblastoma, Ahmed M. Abuzaid

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Vascular Mechanisms of Rhabdomyolysis-induced Acute Kidney Injury, Jeremiah Moyinolu Afolabi

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TCF4 Is a Key Mediator of Cell Identity and Oncogenesis in Neuroblastoma, Nour Aljouda

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Androgen Receptor: A Complex Therapeutic Target in Breast Cancer, Sarah Tinuade Asemota

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Understanding the Host Cellular Response to Astrovirus Infection, Theresa Mary Taggart Bub

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T Cell Responsiveness Through the Ages: Functional Diversity of Age-Dependent Antiviral Responses, Brandi L. Clark

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Investigating Potential Quantitative Trait Loci for Susceptibility to Experimental Autoimmune Encephalomyelitis in the BXD Family of Mice, Margaret Caroline Danehy

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Investigation of Clinically Relevant Fluconazole Resistance Mechanisms in the Fungal Pathogen Candida parapsilosis, Laura Anne Doorley

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Cytochrome P450 1B1 and 12/15 Lipoxygenase Interaction in Paraventricular Nucleus in Angiotensin II-induced Hypertension in Females, Shubha Ranjan Dutta

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The Role of TCR Engagement Strength in Antitumor CD8 T Cell Exhaustion, Xin Lan

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Exogenous Mitochondrial Transfer and IL-6: Modulating Adipocyte Metabolism in Obesity-associated Dysregulation, Soumi Mazumdar

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Modulation of Cerebral Artery Smooth Muscle BK Channel Function by Neurosteroids, Kelsey Caroline Cleland North

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Matrix Gene Splicing and Emergence of Highly Pathogenic Avian Influenza, Christopher Patton

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Development of Novel, Brain Permeable, mPGES-1 Inhibitors for Inflammatory Conditions, Madison Sluter

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The Long-Term Cognitive and Psychological Effects of Mild Traumatic Brain Injury (mTBI), Leah L. Somerville

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Impacts of Habitat, Resource Addition, and Predator Exclusion on Rodent Community Structure and Hantaviruses in the Neotropics, Briana Spruill-Harrell

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Molecular and Cellular Investigations of Prader-Willi Syndrome, Anna K. Victor

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The NTF2L Domain Is a Date Hub That Interacts with SLiMs to Regulate Assembly of Stress Granules, Jinjun Wu

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The Interaction Between Host G3BP and Viral Nucleocapsid Protein Regulates SARS-CoV-2 Replication, Zemin Yang

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A Multi-Faceted Approach to the Alzheimer’s Disease Proteome: From Human to Mouse Models, Jay M. Yarbro

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A Design, Development, and Evaluation of Bio-Patch for Myocardial Tissue Repair, Yaya Zhang

Theses/Dissertations from 2022

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Ribonucleotide Reductase Subunit Switching in Hepatoblastoma Drug Response and Relapse, Anthony Brown

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Risk for Preeclampsia Associated with Nutritional Deficiencies and Modified by APOL1 Genotype, Winter S. Bruner

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Cerebellar Coordination of Neuronal and Behavioral Rhythms, Brittany Correia Chapman

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Olfactory Processing in the Piriform Cortex of Awake, Freely Moving Mice, Ian F. Chapman

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Inflammatory Response Following Hemorrhagic Stroke: The Role of Cytokines, Patrick Devlin

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Immunomodulatory Roles of the Lysosomal Sialidase Neuraminidase 1, Leigh Ellen Fremuth

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The Role and Immunogenicity of CBFA2T3-GLIS2 in Pediatric Acute Megakaryoblastic Leukemia, Elizabeth A. Garfinkle

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Exploring Risk Factors of Alzheimer’s Disease Using Mouse Models, Xian Han

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Developing Targeted Therapies for T-cell Acute Lymphoblastic Leukemia, Jianzhong Hu

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OTULIN's Novel Regulatory Mechanisms in Genotoxic and Inflammatory NF-kB Signaling, Mingqi Li

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A Rodent Animal Model for Forelimb to Lower Jaw Reorganization in Primary Somatosensory Cortex (SI) Barrel Field, Violeta Pellicer Morata

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Mitophagy-Mediated Regulation of ROS Homeostasis During HSC Activation Contributes to Cell Fate, Amber Lynne Smith

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Methods Development in Inflammatory Bowel Disease, Andrew B. Steimke

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A Cloning-Free Recyclable System for CRISPR-Cas9 Mediated Mutant and Reversion Construction in Candida albicans Clinical Isolates, Amanda K. Vogel

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Identification of Therapeutic Targets for Th17 Cell-Mediated Diseases, Jin Wang

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Role of Membrane Contact Sites in the Neuropathogenesis of GM1-Gangliosidosis, Jason Andrew Weesner

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Cellular Dynamics and Disease Outcome of Type 3 Streptococcus pneumoniae Clinical Isolates Differ Between Strains, Taylor Rae Plunkett White

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Characterizing T Cell Features of Atypical Lymphocytes for the Optimization of Adoptive Immunotherapies, Taylor L. Wilson

Theses/Dissertations from 2021

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Effects of Genetics and Sex on Hippocampal Gene Expression and Adolescent Behaviors Following Neonatal Ethanol Exposure in BXD Recombinant Inbred Mice, Jessica A. Baker

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Characterizing and Overcoming Resistance to Aminomethylspectinomycins in Gram-negative Bacteria, Nisha Das

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Investigating the Role of ZNF384 Rearrangements in Acute Leukemia, Kirsten Dickerson

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Environmental and Genetic Factors Affecting Bone Diseases and Phenotypes in Mouse Models, Wei Dong

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The Effect of Cancer Cachexia Progression on the Feeding Regulation of Skeletal Muscle Protein Turnover, Brittany R. Franch

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Role of SMAD2 and SMAD3 on Adipose Tissue Development and Function, Roshan Kumari

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Examination of Antiviral Resistance in Venezuelan Equine Encephalitis Virus, Jasper Lee

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Delineating the Upc2A Regulon in Candida glabrata, Yu Li

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Therapeutic Potential of TRP Channels in the Targeting of Rheumatoid Arthritis Synovial Fibroblasts, Brittany Isabella Schwam

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The Heme-Regulated Inhibitor Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics, Kaitlyn Hill Smith

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Taste Learning in Insular Cortex: Plasticity Is Influenced by Experience Type, Stephanie Marie Staszko

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The Molecular Mechanisms of Estrogen Receptor α on Two Single Nucleotide Polymorphisms to Regulate WNT Signaling in Osteoblasts, Sarocha Suthon

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Adaptive Immunity: From Autoimmune Diseases to Neuroinflammation, Wei Su

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Advancing RNA Virus Discovery and Biology with Whole Genome Sequencing, Mariah Katherine Taylor

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Identification of Effectors of Synergistic Lethality in Candida albicans-Staphylococcus aureus Polymicrobial Intra-abdominal Infection, Olivia Adele Todd

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Ecology of Hantaviruses in Rodent Reservoirs and Their Early Innate Immune Responses in Human Model Systems, Evan Peter Williams

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Genomic Characterization of Sickle Cell Mouse Models for Therapeutic Genome Editing Applications, Kaitly Jensen Woodard

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Identifying the Molecular Cause of Extreme Endoplasmic Reticulum Dilation in Pediatric Osteosarcoma and Its Relationship to the Disease, Rachael Wood

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Genetic Mechanisms of Transcriptional Regulation in Childhood Acute Lymphoblastic Leukemia, Xujie Zhao

Theses/Dissertations from 2020

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Vitamin D Levels Affect Survival in a BCR-ABL Acute Lymphoblastic Leukemia Mouse Model but Do Not Cause Vitamin-Drug Interactions, Kavya Annu

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Integrated Multimodal Genomic Analyses Reveal Novel Mechanisms of Glucocorticoid Resistance in Acute Lymphoblastic Leukemia, Robert J. Autry

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Unraveling Molecular Mechanisms Underlying the Development of Unconventional T Cells, Daniel Eduardo Bastardo Blanco

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Investigation of a Novel Mitophagy Regulatory Pathway and Chemical Inducer, Jane E. Craig

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Validation and Application of a Novel Target-Based Whole-Cell Screen to Identify Antifungal Compounds, Christian Alexander DeJarnette

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The Characterization of Hematopoiesis in Murine Fetal Bone Marrow, Trent Daniel Hall

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Understanding Human Astrovirus from Pathogenesis to Treatment, Virginia Hargest

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Dissecting Drivers of Basal Immunity and Acute Responses to Viral Infection, Aisha Nadia Hegab Souquette

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Attenuation of Interferon Responses in the Obese Host and Ramifications for Influenza Virus Evolution, Rebekah Reed Honce

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Role of Cerebral Vasculature and Effect of Circulating Exosomes in Propagation of Systemic Inflammatory Responses into the Central Nervous System, Mahesh Chandra Kodali

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Genetic Variation and Sex Mediate Differential Responses to ∆-9-tetrahydrocannabinol among Inbred Mice, Cory Parks

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Genomic Instability and the Oncohistone H3K27M Drive Gliomagenesis in a Murine Model, Lee J. Pribyl

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Mechanisms of BAK Activation in the Initiation of Mitochondrial Apoptosis, Geetika Singh

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Conditional Loss of Engrailed 1/2 in Rhombic Lip-Derived Neurons Increases Intrinsic Rhythmicity and Decreases Overall Variability of Eupneic Respiration, Angela P. Taylor

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Systems Genetics and Systems Biology Analysis of Paraquat Effects in BXD Recombinant Inbred Mice, Carolina Del Valle Torres Rojas

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Characterization of Genome-Wide Binding of NUCLEAR-FACTOR I-X in Hematopoietic Progenitor Cells, Megan J. Walker

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Arid1a Haploinsufficiency Initiates Neural Crest Transformation in a Mouse Model of Mycn-driven Neuroblastoma, Kirby A. Wallace

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Selective Targeting of CYP3A5 Through Chemical and Genetic Approaches, William C. Wright

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Eukaryotic Initiation Factor 5A2 (EIF5A2) Contributes to Ovarian Tumor Growth and Metastasis, Guannan Zhao

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Biochemical and Structural Characterization of the Atg8/LC3 Lipidation Pathway, Yumei Zheng

Theses/Dissertations from 2019

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Reverse Zoonosis of Pandemic A(H1N1)pdm09 Influenza Viruses at the Swine/Human Interface, Daniel Gene Darnell

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Roles of γδ T Cells in Influenza Infections and Methods for TCR Expression and Characterization, Xizhi Guo

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Investigation of Cell-Type-Specific Effects and Synergistic Interactions Between Genes in Duplication 15q Syndrome, Kevin A. Hope

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Regulation of CYP3A5 in Pancreatic Ductal Adenocarcinoma, Jessica D. Hoyer

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The Role of Secretory Phospholipase A2 Group IIA in Obesity and Metabolism, Michael S. Kuefner

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Transcriptional Regulation of NLRC4 Inflammasome by IRF8, Ein Lee

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Using Genetic Diversity to Understand Susceptibility to Cognitive Decline in Aging and Alzheimer’s Disease, Sarah M. Neuner

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Study of Natural Killer Cells and Their Therapeutic Role in Pediatric Cancer, Hong Ha Rosa Nguyen

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Delineating the Mechanisms of Misfolded Endoplasmic Reticulum (ER) Luminal Protein Retrotranslocation for ER-Associated Degradation, Christina Oikonomou

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Fear Learning and the Olfactory Bulb: Neural Correlates of Behavioral Fear Generalization, Jordan Marie Ross

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Challenging the Paradigm of Clinical Triazole Resistance in Aspergillus fumigatus, Jeffrey Michael Rybak

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Antibiotic Drug Discovery Targeting Bacterial Metabolism, Miranda J. Wallace

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Investigation of Riluzole’s Synaptic Protection Mechanism Through HSF1-BDNF Axis, Yi Zhang

Theses/Dissertations from 2018

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Characterization of the Hepatotoxicity of Rifampicin and Isoniazid, Christopher T. Brewer

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Molecular Interplay of Chromatin Remodeling Factor BRG1 and Transcription Factor STAT3 Regulates Stemness, Chemosensitivity and Tumorigenicity of Glioma Tumor Initiating Cells, Debolina Ganguly

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Understanding the Impact of BCRP and PGP Efflux Transporters on the Disposition of Their Endogenous, Xenobiotic and Dietary Substrates, Samit Ganguly

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The Tumor Microenvironment Regulates Retinoblastoma Cell Survival, Zachary K. Goldsmith

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Signaling Induced by Inflammatory Mediators in the Rodent Pulmonary Microvasculature, Rachel Escue Helms

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The Role of BiP Co-chaperone SIL1 in Marinesco-Sjögren Syndrome Pathogenesis, Viraj Paresh Ichhaporia

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PIP2 Modulation of Afterhyperpolarizations in Magnocellular Supraoptic Neurons, Matthew Karl Kirchner