Theses/Dissertations from 2023
Inhibition of KDM4 with QC6352 to Target High-Risk Neuroblastoma, Ahmed M. Abuzaid
Vascular Mechanisms of Rhabdomyolysis-induced Acute Kidney Injury, Jeremiah Moyinolu Afolabi
TCF4 Is a Key Mediator of Cell Identity and Oncogenesis in Neuroblastoma, Nour Aljouda
Investigation of Clinically Relevant Fluconazole Resistance Mechanisms in the Fungal Pathogen Candida parapsilosis, Laura Anne Doorley
Cytochrome P450 1B1 and 12/15 Lipoxygenase Interaction in Paraventricular Nucleus in Angiotensin II-induced Hypertension in Females, Shubha Ranjan Dutta
Modulation of Cerebral Artery Smooth Muscle BK Channel Function by Neurosteroids, Kelsey Caroline Cleland North
Development of Novel, Brain Permeable, mPGES-1 Inhibitors for Inflammatory Conditions, Madison Sluter
Impacts of Habitat, Resource Addition, and Predator Exclusion on Rodent Community Structure and Hantaviruses in the Neotropics, Briana Spruill-Harrell
Molecular and Cellular Investigations of Prader-Willi Syndrome, Anna K. Victor
The Interaction Between Host G3BP and Viral Nucleocapsid Protein Regulates SARS-CoV-2 Replication, Zemin Yang
A Design, Development, and Evaluation of Bio-Patch for Myocardial Tissue Repair, Yaya Zhang
Theses/Dissertations from 2022
Ribonucleotide Reductase Subunit Switching in Hepatoblastoma Drug Response and Relapse, Anthony Brown
Risk for Preeclampsia Associated with Nutritional Deficiencies and Modified by APOL1 Genotype, Winter S. Bruner
Cerebellar Coordination of Neuronal and Behavioral Rhythms, Brittany Correia Chapman
Olfactory Processing in the Piriform Cortex of Awake, Freely Moving Mice, Ian F. Chapman
Inflammatory Response Following Hemorrhagic Stroke: The Role of Cytokines, Patrick Devlin
Immunomodulatory Roles of the Lysosomal Sialidase Neuraminidase 1, Leigh Ellen Fremuth
The Role and Immunogenicity of CBFA2T3-GLIS2 in Pediatric Acute Megakaryoblastic Leukemia, Elizabeth A. Garfinkle
Exploring Risk Factors of Alzheimer’s Disease Using Mouse Models, Xian Han
Developing Targeted Therapies for T-cell Acute Lymphoblastic Leukemia, Jianzhong Hu
OTULIN's Novel Regulatory Mechanisms in Genotoxic and Inflammatory NF-kB Signaling, Mingqi Li
A Rodent Animal Model for Forelimb to Lower Jaw Reorganization in Primary Somatosensory Cortex (SI) Barrel Field, Violeta Pellicer Morata
Mitophagy-Mediated Regulation of ROS Homeostasis During HSC Activation Contributes to Cell Fate, Amber Lynne Smith
Methods Development in Inflammatory Bowel Disease, Andrew B. Steimke
A Cloning-Free Recyclable System for CRISPR-Cas9 Mediated Mutant and Reversion Construction in Candida albicans Clinical Isolates, Amanda K. Vogel
Identification of Therapeutic Targets for Th17 Cell-Mediated Diseases, Jin Wang
Role of Membrane Contact Sites in the Neuropathogenesis of GM1-Gangliosidosis, Jason Andrew Weesner
Cellular Dynamics and Disease Outcome of Type 3 Streptococcus pneumoniae Clinical Isolates Differ Between Strains, Taylor Rae Plunkett White
Characterizing T Cell Features of Atypical Lymphocytes for the Optimization of Adoptive Immunotherapies, Taylor L. Wilson
Theses/Dissertations from 2021
Effects of Genetics and Sex on Hippocampal Gene Expression and Adolescent Behaviors Following Neonatal Ethanol Exposure in BXD Recombinant Inbred Mice, Jessica A. Baker
Characterizing and Overcoming Resistance to Aminomethylspectinomycins in Gram-negative Bacteria, Nisha Das
Investigating the Role of ZNF384 Rearrangements in Acute Leukemia, Kirsten Dickerson
Environmental and Genetic Factors Affecting Bone Diseases and Phenotypes in Mouse Models, Wei Dong
The Effect of Cancer Cachexia Progression on the Feeding Regulation of Skeletal Muscle Protein Turnover, Brittany R. Franch
Role of SMAD2 and SMAD3 on Adipose Tissue Development and Function, Roshan Kumari
Examination of Antiviral Resistance in Venezuelan Equine Encephalitis Virus, Jasper Lee
Delineating the Upc2A Regulon in Candida glabrata, Yu Li
Therapeutic Potential of TRP Channels in the Targeting of Rheumatoid Arthritis Synovial Fibroblasts, Brittany Isabella Schwam
The Heme-Regulated Inhibitor Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics, Kaitlyn Hill Smith
Taste Learning in Insular Cortex: Plasticity Is Influenced by Experience Type, Stephanie Marie Staszko
The Molecular Mechanisms of Estrogen Receptor α on Two Single Nucleotide Polymorphisms to Regulate WNT Signaling in Osteoblasts, Sarocha Suthon
Adaptive Immunity: From Autoimmune Diseases to Neuroinflammation, Wei Su
Advancing RNA Virus Discovery and Biology with Whole Genome Sequencing, Mariah Katherine Taylor
Identification of Effectors of Synergistic Lethality in Candida albicans-Staphylococcus aureus Polymicrobial Intra-abdominal Infection, Olivia Adele Todd
Ecology of Hantaviruses in Rodent Reservoirs and Their Early Innate Immune Responses in Human Model Systems, Evan Peter Williams
Genomic Characterization of Sickle Cell Mouse Models for Therapeutic Genome Editing Applications, Kaitly Jensen Woodard
Genetic Mechanisms of Transcriptional Regulation in Childhood Acute Lymphoblastic Leukemia, Xujie Zhao
Theses/Dissertations from 2020
Integrated Multimodal Genomic Analyses Reveal Novel Mechanisms of Glucocorticoid Resistance in Acute Lymphoblastic Leukemia, Robert J. Autry
Unraveling Molecular Mechanisms Underlying the Development of Unconventional T Cells, Daniel Eduardo Bastardo Blanco
Investigation of a Novel Mitophagy Regulatory Pathway and Chemical Inducer, Jane E. Craig
Validation and Application of a Novel Target-Based Whole-Cell Screen to Identify Antifungal Compounds, Christian Alexander DeJarnette
The Characterization of Hematopoiesis in Murine Fetal Bone Marrow, Trent Daniel Hall
Understanding Human Astrovirus from Pathogenesis to Treatment, Virginia Hargest
Dissecting Drivers of Basal Immunity and Acute Responses to Viral Infection, Aisha Nadia Hegab Souquette
Attenuation of Interferon Responses in the Obese Host and Ramifications for Influenza Virus Evolution, Rebekah Reed Honce
Role of Cerebral Vasculature and Effect of Circulating Exosomes in Propagation of Systemic Inflammatory Responses into the Central Nervous System, Mahesh Chandra Kodali
Genetic Variation and Sex Mediate Differential Responses to ∆-9-tetrahydrocannabinol among Inbred Mice, Cory Parks
Genomic Instability and the Oncohistone H3K27M Drive Gliomagenesis in a Murine Model, Lee J. Pribyl
Mechanisms of BAK Activation in the Initiation of Mitochondrial Apoptosis, Geetika Singh
Conditional Loss of Engrailed 1/2 in Rhombic Lip-Derived Neurons Increases Intrinsic Rhythmicity and Decreases Overall Variability of Eupneic Respiration, Angela P. Taylor
Systems Genetics and Systems Biology Analysis of Paraquat Effects in BXD Recombinant Inbred Mice, Carolina Del Valle Torres Rojas
Characterization of Genome-Wide Binding of NUCLEAR-FACTOR I-X in Hematopoietic Progenitor Cells, Megan J. Walker
Arid1a Haploinsufficiency Initiates Neural Crest Transformation in a Mouse Model of Mycn-driven Neuroblastoma, Kirby A. Wallace
Selective Targeting of CYP3A5 Through Chemical and Genetic Approaches, William C. Wright
Eukaryotic Initiation Factor 5A2 (EIF5A2) Contributes to Ovarian Tumor Growth and Metastasis, Guannan Zhao
Biochemical and Structural Characterization of the Atg8/LC3 Lipidation Pathway, Yumei Zheng
Theses/Dissertations from 2019
Reverse Zoonosis of Pandemic A(H1N1)pdm09 Influenza Viruses at the Swine/Human Interface, Daniel Gene Darnell
Roles of γδ T Cells in Influenza Infections and Methods for TCR Expression and Characterization, Xizhi Guo
Investigation of Cell-Type-Specific Effects and Synergistic Interactions Between Genes in Duplication 15q Syndrome, Kevin A. Hope
Regulation of CYP3A5 in Pancreatic Ductal Adenocarcinoma, Jessica D. Hoyer
The Role of Secretory Phospholipase A2 Group IIA in Obesity and Metabolism, Michael S. Kuefner
Transcriptional Regulation of NLRC4 Inflammasome by IRF8, Ein Lee
Using Genetic Diversity to Understand Susceptibility to Cognitive Decline in Aging and Alzheimer’s Disease, Sarah M. Neuner
Study of Natural Killer Cells and Their Therapeutic Role in Pediatric Cancer, Hong Ha Rosa Nguyen
Delineating the Mechanisms of Misfolded Endoplasmic Reticulum (ER) Luminal Protein Retrotranslocation for ER-Associated Degradation, Christina Oikonomou
Fear Learning and the Olfactory Bulb: Neural Correlates of Behavioral Fear Generalization, Jordan Marie Ross
Challenging the Paradigm of Clinical Triazole Resistance in Aspergillus fumigatus, Jeffrey Michael Rybak
Antibiotic Drug Discovery Targeting Bacterial Metabolism, Miranda J. Wallace
Investigation of Riluzole’s Synaptic Protection Mechanism Through HSF1-BDNF Axis, Yi Zhang
Theses/Dissertations from 2018
Characterization of the Hepatotoxicity of Rifampicin and Isoniazid, Christopher T. Brewer
Understanding the Impact of BCRP and PGP Efflux Transporters on the Disposition of Their Endogenous, Xenobiotic and Dietary Substrates, Samit Ganguly
The Tumor Microenvironment Regulates Retinoblastoma Cell Survival, Zachary K. Goldsmith
Signaling Induced by Inflammatory Mediators in the Rodent Pulmonary Microvasculature, Rachel Escue Helms
The Role of BiP Co-chaperone SIL1 in Marinesco-Sjögren Syndrome Pathogenesis, Viraj Paresh Ichhaporia
PIP2 Modulation of Afterhyperpolarizations in Magnocellular Supraoptic Neurons, Matthew Karl Kirchner
The Role of Exosomal Transport of Viral Agents in Persistent HIV Pathogenesis, Benjamin J. Patters
An Interface of the Taste and Reward Systems in the Brainstem and Its Role in Feeding, Louis Saites
Role of SMARCE1 and BHLHE40 in Breast Cancer Metastasis, Aarti Sethuraman
Pathogenicity and Protection Mediated by a Single TCRβ in Experimental Autoimmune Encephalomyelitis, Tianhua Wu
Protein Trafficking of BK Channel β1 Subunits in Cerebral Artery Myocytes, Xue Zhai
Roles of Cytosolic Nucleic Acid Sensors in Cancer and Infection, Qifan Zhu
Theses/Dissertations from 2017
Investigating the Role of Dispatched in Hedgehog Ligand Transport and Delivery, William Bodeen
Metabolic Regulation of Cellular Signaling, Rashid John Darbandi
THE ROLE OF HSF1 PROTEIN REGULATION ON NEURODEGENERATION, Eunhee Kim
Using S. pombe to Study the Biological Roles of the Histone Deacetylases Sir2 and Clr3 and the DEAD-Box RNA Helicase Ded1, Brandon Ray Lowe
Assessing Neuronal Synchrony and Brain Function Through Local Field Potential and Spike Analysis, Samuel Stuart McAfee
Habituation and Dishabituation in the Olfactory Bulb: From Neural Responses to Behavior, Mary Cameron Ogg