Theses/Dissertations from 2020
Eukaryotic Initiation Factor 5A2 (EIF5A2) Contributes to Ovarian Tumor Growth and Metastasis, Guannan Zhao
Biochemical and Structural Characterization of the Atg8/LC3 Lipidation Pathway, Yumei Zheng
Theses/Dissertations from 2019
Reverse Zoonosis of Pandemic A(H1N1)pdm09 Influenza Viruses at the Swine/Human Interface, Daniel Gene Darnell
Roles of γδ T Cells in Influenza Infections and Methods for TCR Expression and Characterization, Xizhi Guo
Investigation of Cell-Type-Specific Effects and Synergistic Interactions Between Genes in Duplication 15q Syndrome, Kevin A. Hope
Regulation of CYP3A5 in Pancreatic Ductal Adenocarcinoma, Jessica D. Hoyer
The Role of Secretory Phospholipase A2 Group IIA in Obesity and Metabolism, Michael S. Kuefner
Transcriptional Regulation of NLRC4 Inflammasome by IRF8, Ein Lee
Using Genetic Diversity to Understand Susceptibility to Cognitive Decline in Aging and Alzheimer’s Disease, Sarah M. Neuner
Study of Natural Killer Cells and Their Therapeutic Role in Pediatric Cancer, Hong Ha Rosa Nguyen
Delineating the Mechanisms of Misfolded Endoplasmic Reticulum (ER) Luminal Protein Retrotranslocation for ER-Associated Degradation, Christina Oikonomou
Fear Learning and the Olfactory Bulb: Neural Correlates of Behavioral Fear Generalization, Jordan Marie Ross
Challenging the Paradigm of Clinical Triazole Resistance in Aspergillus fumigatus, Jeffrey Michael Rybak
Antibiotic Drug Discovery Targeting Bacterial Metabolism, Miranda J. Wallace
Investigation of Riluzole’s Synaptic Protection Mechanism Through HSF1-BDNF Axis, Yi Zhang
Theses/Dissertations from 2018
Characterization of the Hepatotoxicity of Rifampicin and Isoniazid, Christopher T. Brewer
Understanding the Impact of BCRP and PGP Efflux Transporters on the Disposition of Their Endogenous, Xenobiotic and Dietary Substrates, Samit Ganguly
The Tumor Microenvironment Regulates Retinoblastoma Cell Survival, Zachary K. Goldsmith
Signaling Induced by Inflammatory Mediators in the Rodent Pulmonary Microvasculature, Rachel Escue Helms
The Role of BiP Co-chaperone SIL1 in Marinesco-Sjögren Syndrome Pathogenesis, Viraj Paresh Ichhaporia
PIP2 Modulation of Afterhyperpolarizations in Magnocellular Supraoptic Neurons, Matthew Karl Kirchner
The Role of Exosomal Transport of Viral Agents in Persistent HIV Pathogenesis, Benjamin J. Patters
An Interface of the Taste and Reward Systems in the Brainstem and Its Role in Feeding, Louis Saites
Role of SMARCE1 and BHLHE40 in Breast Cancer Metastasis, Aarti Sethuraman
Pathogenicity and Protection Mediated by a Single TCRβ in Experimental Autoimmune Encephalomyelitis, Tianhua Wu
Protein Trafficking of BK Channel β1 Subunits in Cerebral Artery Myocytes, Xue Zhai
Roles of Cytosolic Nucleic Acid Sensors in Cancer and Infection, Qifan Zhu
Theses/Dissertations from 2017
Investigating the Role of Dispatched in Hedgehog Ligand Transport and Delivery, William Bodeen
Metabolic Regulation of Cellular Signaling, Rashid John Darbandi
THE ROLE OF HSF1 PROTEIN REGULATION ON NEURODEGENERATION, Eunhee Kim
Using S. pombe to Study the Biological Roles of the Histone Deacetylases Sir2 and Clr3 and the DEAD-Box RNA Helicase Ded1, Brandon Ray Lowe
Assessing Neuronal Synchrony and Brain Function Through Local Field Potential and Spike Analysis, Samuel Stuart McAfee
Habituation and Dishabituation in the Olfactory Bulb: From Neural Responses to Behavior, Mary Cameron Ogg
Role of Dendritic Cells in Pathology of Respiratory Syncytial Virus Infection in Neonates, Bishwas Shrestha
Biophysical and Biochemical Screening Approaches for Antimicrobial Drug Discovery Targeting S. aureus ClpP, Aman Preet Singh
Revealing a Non-canonical Role of Anti-apoptotic MCL-1 in Early Embryonic Development, Xue Yang
Theses/Dissertations from 2016
Interaction Between Two E3 ligases, NEDD8ylated Cullin and HHARI, Kheewoong Baek
Investigating the Regulation and Function of the NR4A Nuclear Receptors in Cancer, Jordan A. Beard
The Nucleolar Protein Nucleophosmin Undergoes Liquid-Liquid Phase Separation with Arginine-Rich Nucleolar Proteins through Weak, Multivalent Electrostatic Interactions, Jaclyn Alicia Cika
Novel Oncogenic Drivers in Pediatric Gliomagenesis, Alexander K. Diaz
Antibodies to Heterogenous Nuclear Ribonucleoprotein A1 Penetrate Neurons Leading to Multiple Downstream Effects Resulting in Neurodegeneration, Joshua Nathan Douglas
Assessment of the Zoonotic Potential of a Novel Bovine Influenza Virus, Laura Evelyn Eckard
The Roles of Nuclear Receptor NR4A1 in Cancer Cell Proliferation and Skeletal Muscle Differentiation, Alexa Farmer
The Role of Drak2 in T Cell Function and Autoimmunity, Tarsha L. Harris
Regulation of IRF-3-Dependent Innate Immune Signaling Pathway by the PLpro Domain of Non-Structural Protein 3 (NSP3) of Severe Acute Respiratory Syndrome (SARS) Coronavirus, Sandra Nicole Lester
Dissecting the Novel Roles of TRIM56 in Antiviral Innate Immunity, Baoming Liu
Endosomal Trafficking as a Determinant of Antifungal Tolerance in the Pathogenic Fungus Candida albicans, Arturo Luis Luna
Role of Occludin in the Regulation of Epithelial Tight Junctions, Bhargavi Manda
Neuroanatomical Maps and Taste Reactivity to Sweet, Umami, and Bitter Taste in the PBN of C57BL/6J Mice, Jennifer Marie Saputra
Pten Signaling in Regulatory T Cells and Inflammatory Disease, Sharad Krishna Shrestha
Evaluating the Therapeutic Effect of an Hsp90 Inhibitor in Mouse Models of Alzheimer’s Disease, Bin Wang
Dissecting the Physiological Roles of ULK1/2 in the Mouse Brain, Bo Wang
Understanding Structural And Functional Mechanisms of Emi1 Inhibition of the Anaphase Promoting Complex, Edmond Randall Watson
Environmental Signaling through the Target of Rapamycin Complex 1 (TORC1) and the Regulation of Epigenetic Mechanisms, Jason J. Workman
Repeated Zolpidem Treatment Effects on Sedative Tolerance, Withdrawal, mRNA Levels, and Protein Expression, Brittany T. Wright
Theses/Dissertations from 2015
Genetic Control of Survival and Weight Loss during Pneumonic Burkholderia pseudomallei (Bp) Infection, Felicia D. Emery
Integration of ATM, ATR, and DNA-PKcs Signaling Maintains Genome Integrity During Neurogenesis, Vanessa D. Enriquez-Rios
Reprogramming to Pluripotency Using Small Molecule Compounds, Brittany E. Greenberg
Molecular Mechanisms Underlying Alcohol-Induced Cerebral Artery Smooth Muscle BK Channel Inhibition and Eventual Cerebral Vasoconstriction, Guruprasad Kuntamallappanavar
Adverse Effects of Asparaginase in Pediatric Patients with Acute Lymphoblastic Leukemia, Chengcheng Liu
Development of Oral Vaccines Against Lyme Disease, Rita Raquel dos Anjos de Carvalho e Melo
Functional Analysis of Genomic Variation and Impact on Molecular and Higher Order Phenotypes, Ashutosh Kumar Pandey
Effects of Cocaine Sensitization on Drug Self-Administration, Mesocorticolimbic SAPAP Levels, and Prefrontal Ionotropic Glutamate Receptors, Kyle Christopher Summers
Structural-based Investigation of FAK and P130Cas in Focal Adhesion, Chi Zhang
Theses/Dissertations from 2014
Preclinical Evaluation of a Novel Polysaccharide Hydrogel for Local Chemotherapy Delivery to Solid Tumors, Elizabeth Diana Barker
Adenosine Production Is Essential for Closing the Critical Period of Cortical Plasticity, Rachel A. Chassan
The Mi-2 Homolog Mit1 Actively Positions Nucleosomes Within Heterochromatin to Suppress Transcription, Kevin M. Creamer
Molecular Characterization of Glioblastoma Cancer Stem Cells, Jo Meagan Garner
Functional and Genetic Analysis of Choroid Plexus Development in Zebrafish, Hannah Elizabeth Henson
Group IV Cytosolic Phospholipase A2α Is Critical for the Development of Angiotensin II-Induced Hypertension and Associated Pathogenesis, Nayaab Shehbaz Khan
Effect of Nedd4 Haploinsufficiency on Insulin Sensitivity, Adiposity and Neuronal Behaviors, Jingjing Li
Persistant GATA2 Expression Promotes Self-Renewal of Myeloid Progenitors and Blocks Lymphoid Differentiation., Satish Kumar Nandakumar
Novel Insights into the Role of the Smoothened Cysteine Rich Domain in Hedgehog Signalling, Rajashree Rana
Characterization of Cre Mouse Models to Target CNS Barriers for Generating Conditional Knockouts of ABC Transporters, Rachel L. Scheib
MRP4-Dependent Regulation of Fibroblast Migration, Chandrima Sinha
Genetic and Chemical Dissection of BloodBrain Barrier Development in Zebrafish, Robyn Anne Umans
The Role of MCL-1 in the Heart: Gateway from Life to Death, Xi Wang
Strengths and Weaknesses of Hybrid TPR Technology for Obtaining Structural and Mechanistic Insights into TPR Proteins, Shanshan Yu
Autoimmune Susceptibility Imposed by Public TCRβ Chains, Yunqian Zhao
Theses/Dissertations from 2013
Toll-like Receptors 2 and 9 Are Important for Innate Immune Cell Activation and Recruitment in Hypersensitivity Pneumonitis, Kelly J. Andrews
Macromolecular Complexes of Cystic Fibrosis Transmembrane Conductance Regulator Alter Fluid Transport in inflammatory Bowel Disorders, Kavisha Arora
Adenylyl Cyclase 2 Selectively Regulates IL-6 Expression in Human Bronchial Smooth Muscle Cells, Amy Sue Bogard
Development and Characterization of a Recombinant Vesicular Stomatitis Virus (rVSV) for the Treatment of Glioblastoma, Erika A. Dillard
Virologic Factors Contributing to the Genetic Diversification of Influenza Viruses Circulating in North American Swine, Thomas Paul Fabrizio II
ERG11-Mediated Azole Resistance in Candida albicans, Stephanie Ann Flowers
Functional Study of Hemogen Knockout Mouse Model, Peng Gao
A Novel Mechanism of Enhanced Susceptibility to Bacterial Pneumonia in Influenza-infected Hosts, Hazem Elsayed Ghoneim
NKG2D Ligands in Cancer, Neha Das Gupta
Developmental Characterization of the Choroid Plexus in Sialidosis (Neu1 Deficient) Mice, Danielle Lee Helton
Tetraspanin CD9: Contributions to Cancer Cell and Vascular Cell Phenotypes from the Sixth Man, Michael James Herr II
Determinants of Upper Genital Tract Complications in a Chlamydial Urogenital Mouse Model, Enitra N. Jones
In vitro and In vivo Characterization of the Infection Efficiency of a Modified Retrovirus Envelope Glycoprotein for Targeting Gene Transduction, Robin L. Krueger
Identification of Novel HIF1A Target Genes That Regulate Tumor Progression and Metastasis, Danielle L. Peacock
Full-Gestational Exposure to Nicotine and Ethanol Results in Long-Term Dysregulation in the Ventral Tegmental Area, Emily Elizabeth Roguski