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Theses/Dissertations from 2021

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Effects of Genetics and Sex on Hippocampal Gene Expression and Adolescent Behaviors Following Neonatal Ethanol Exposure in BXD Recombinant Inbred Mice, Jessica A. Baker

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Investigating the Role of ZNF384 Rearrangements in Acute Leukemia, Kirsten Dickerson

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Role of SMAD2 and SMAD3 on Adipose Tissue Development and Function, Roshan Kumari

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Delineating the Upc2A Regulon in Candida glabrata, Yu Li

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Therapeutic Potential of TRP Channels in the Targeting of Rheumatoid Arthritis Synovial Fibroblasts, Brittany Isabella Schwam

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The Heme-Regulated Inhibitor Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics, Kaitlyn Hill Smith

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Taste Learning in Insular Cortex: Plasticity Is Influenced by Experience Type, Stephanie Marie Staszko

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The Molecular Mechanisms of Estrogen Receptor α on Two Single Nucleotide Polymorphisms to Regulate WNT Signaling in Osteoblasts, Sarocha Suthon

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Adaptive Immunity: From Autoimmune Diseases to Neuroinflammation, Wei Su

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Advancing RNA Virus Discovery and Biology with Whole Genome Sequencing, Mariah Katherine Taylor

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Identification of Effectors of Synergistic Lethality in Candida albicans-Staphylococcus aureus Polymicrobial Intra-abdominal Infection, Olivia Adele Todd

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Genomic Characterization of Sickle Cell Mouse Models for Therapeutic Genome Editing Applications, Kaitly Jensen Woodard

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Genetic Mechanisms of Transcriptional Regulation in Childhood Acute Lymphoblastic Leukemia, Xujie Zhao

Theses/Dissertations from 2020

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Vitamin D Levels Affect Survival in a BCR-ABL Acute Lymphoblastic Leukemia Mouse Model but Do Not Cause Vitamin-Drug Interactions, Kavya Annu

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Integrated Multimodal Genomic Analyses Reveal Novel Mechanisms of Glucocorticoid Resistance in Acute Lymphoblastic Leukemia, Robert J. Autry

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Unraveling Molecular Mechanisms Underlying the Development of Unconventional T Cells, Daniel Eduardo Bastardo Blanco

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Investigation of a Novel Mitophagy Regulatory Pathway and Chemical Inducer, Jane E. Craig

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Validation and Application of a Novel Target-Based Whole-Cell Screen to Identify Antifungal Compounds, Christian Alexander DeJarnette

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The Characterization of Hematopoiesis in Murine Fetal Bone Marrow, Trent Daniel Hall

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Understanding Human Astrovirus from Pathogenesis to Treatment, Virginia Hargest

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Dissecting Drivers of Basal Immunity and Acute Responses to Viral Infection, Aisha Nadia Hegab Souquette

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Attenuation of Interferon Responses in the Obese Host and Ramifications for Influenza Virus Evolution, Rebekah Reed Honce

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Role of Cerebral Vasculature and Effect of Circulating Exosomes in Propagation of Systemic Inflammatory Responses into the Central Nervous System, Mahesh Chandra Kodali

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Genetic Variation and Sex Mediate Differential Responses to ∆-9-tetrahydrocannabinol among Inbred Mice, Cory Parks

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Genomic Instability and the Oncohistone H3K27M Drive Gliomagenesis in a Murine Model, Lee J. Pribyl

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Mechanisms of BAK Activation in the Initiation of Mitochondrial Apoptosis, Geetika Singh

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Conditional Loss of Engrailed 1/2 in Rhombic Lip-Derived Neurons Increases Intrinsic Rhythmicity and Decreases Overall Variability of Eupneic Respiration, Angela P. Taylor

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Systems Genetics and Systems Biology Analysis of Paraquat Effects in BXD Recombinant Inbred Mice, Carolina Del Valle Torres Rojas

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Characterization of Genome-Wide Binding of NUCLEAR-FACTOR I-X in Hematopoietic Progenitor Cells, Megan J. Walker

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Arid1a Haploinsufficiency Initiates Neural Crest Transformation in a Mouse Model of Mycn-driven Neuroblastoma, Kirby A. Wallace

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Selective Targeting of CYP3A5 Through Chemical and Genetic Approaches, William C. Wright

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Eukaryotic Initiation Factor 5A2 (EIF5A2) Contributes to Ovarian Tumor Growth and Metastasis, Guannan Zhao

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Biochemical and Structural Characterization of the Atg8/LC3 Lipidation Pathway, Yumei Zheng

Theses/Dissertations from 2019

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Reverse Zoonosis of Pandemic A(H1N1)pdm09 Influenza Viruses at the Swine/Human Interface, Daniel Gene Darnell

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Roles of γδ T Cells in Influenza Infections and Methods for TCR Expression and Characterization, Xizhi Guo

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Investigation of Cell-Type-Specific Effects and Synergistic Interactions Between Genes in Duplication 15q Syndrome, Kevin A. Hope

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Regulation of CYP3A5 in Pancreatic Ductal Adenocarcinoma, Jessica D. Hoyer

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The Role of Secretory Phospholipase A2 Group IIA in Obesity and Metabolism, Michael S. Kuefner

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Transcriptional Regulation of NLRC4 Inflammasome by IRF8, Ein Lee

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Using Genetic Diversity to Understand Susceptibility to Cognitive Decline in Aging and Alzheimer’s Disease, Sarah M. Neuner

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Study of Natural Killer Cells and Their Therapeutic Role in Pediatric Cancer, Hong Ha Rosa Nguyen

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Delineating the Mechanisms of Misfolded Endoplasmic Reticulum (ER) Luminal Protein Retrotranslocation for ER-Associated Degradation, Christina Oikonomou

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Fear Learning and the Olfactory Bulb: Neural Correlates of Behavioral Fear Generalization, Jordan Marie Ross

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Challenging the Paradigm of Clinical Triazole Resistance in Aspergillus fumigatus, Jeffrey Michael Rybak

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Antibiotic Drug Discovery Targeting Bacterial Metabolism, Miranda J. Wallace

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Investigation of Riluzole’s Synaptic Protection Mechanism Through HSF1-BDNF Axis, Yi Zhang

Theses/Dissertations from 2018

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Characterization of the Hepatotoxicity of Rifampicin and Isoniazid, Christopher T. Brewer

Molecular Interplay of Chromatin Remodeling Factor BRG1 and Transcription Factor STAT3 Regulates Stemness, Chemosensitivity and Tumorigenicity of Glioma Tumor Initiating Cells, Debolina Ganguly

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Understanding the Impact of BCRP and PGP Efflux Transporters on the Disposition of Their Endogenous, Xenobiotic and Dietary Substrates, Samit Ganguly

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The Tumor Microenvironment Regulates Retinoblastoma Cell Survival, Zachary K. Goldsmith

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Signaling Induced by Inflammatory Mediators in the Rodent Pulmonary Microvasculature, Rachel Escue Helms

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The Role of BiP Co-chaperone SIL1 in Marinesco-Sjögren Syndrome Pathogenesis, Viraj Paresh Ichhaporia

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PIP2 Modulation of Afterhyperpolarizations in Magnocellular Supraoptic Neurons, Matthew Karl Kirchner

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The Role of Exosomal Transport of Viral Agents in Persistent HIV Pathogenesis, Benjamin J. Patters

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An Interface of the Taste and Reward Systems in the Brainstem and Its Role in Feeding, Louis Saites

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Role of SMARCE1 and BHLHE40 in Breast Cancer Metastasis, Aarti Sethuraman

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Pathogenicity and Protection Mediated by a Single TCRβ in Experimental Autoimmune Encephalomyelitis, Tianhua Wu

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Protein Trafficking of BK Channel β1 Subunits in Cerebral Artery Myocytes, Xue Zhai

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Roles of Cytosolic Nucleic Acid Sensors in Cancer and Infection, Qifan Zhu

Theses/Dissertations from 2017

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Investigating the Role of Dispatched in Hedgehog Ligand Transport and Delivery, William Bodeen

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Metabolic Regulation of Cellular Signaling, Rashid John Darbandi

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THE ROLE OF HSF1 PROTEIN REGULATION ON NEURODEGENERATION, Eunhee Kim

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Using S. pombe to Study the Biological Roles of the Histone Deacetylases Sir2 and Clr3 and the DEAD-Box RNA Helicase Ded1, Brandon Ray Lowe

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Assessing Neuronal Synchrony and Brain Function Through Local Field Potential and Spike Analysis, Samuel Stuart McAfee

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Habituation and Dishabituation in the Olfactory Bulb: From Neural Responses to Behavior, Mary Cameron Ogg

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Pitx3Null Mutant (Striatal Dopamine-Deficient) Mice Have Exaggerated Spiny Projection Neuron Responses to l-DOPA and D1 Agonism and Lack Baseline Striatonigral Spiking, Ben Sagot

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Role of Dendritic Cells in Pathology of Respiratory Syncytial Virus Infection in Neonates, Bishwas Shrestha

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Biophysical and Biochemical Screening Approaches for Antimicrobial Drug Discovery Targeting S. aureus ClpP, Aman Preet Singh

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Genome-scale Precision Proteomics Identifies Cancer Signaling Networks and Therapeutic Vulnerabilities, Hong Wang

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Revealing a Non-canonical Role of Anti-apoptotic MCL-1 in Early Embryonic Development, Xue Yang

Theses/Dissertations from 2016

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Interaction Between Two E3 ligases, NEDD8ylated Cullin and HHARI, Kheewoong Baek

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Investigating the Regulation and Function of the NR4A Nuclear Receptors in Cancer, Jordan A. Beard

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The Nucleolar Protein Nucleophosmin Undergoes Liquid-Liquid Phase Separation with Arginine-Rich Nucleolar Proteins through Weak, Multivalent Electrostatic Interactions, Jaclyn Alicia Cika

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Novel Oncogenic Drivers in Pediatric Gliomagenesis, Alexander K. Diaz

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Antibodies to Heterogenous Nuclear Ribonucleoprotein A1 Penetrate Neurons Leading to Multiple Downstream Effects Resulting in Neurodegeneration, Joshua Nathan Douglas

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Assessment of the Zoonotic Potential of a Novel Bovine Influenza Virus, Laura Evelyn Eckard

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The Roles of Nuclear Receptor NR4A1 in Cancer Cell Proliferation and Skeletal Muscle Differentiation, Alexa Farmer

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Examining the Roles of GABAA Receptor Subtypes in Anxiety and Anxiolysis: Focusing on the Basolateral Amygdala, Yudong Gao

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Mild Traumatic Brain Injury with Associated Visual System Dysfunction: Investigating Histopathology, Functional Correlates, and a Novel Therapeutic Immune Modulator, Natalie M. Guley

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The Role of Drak2 in T Cell Function and Autoimmunity, Tarsha L. Harris

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Regulation of IRF-3-Dependent Innate Immune Signaling Pathway by the PLpro Domain of Non-Structural Protein 3 (NSP3) of Severe Acute Respiratory Syndrome (SARS) Coronavirus, Sandra Nicole Lester

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Dissecting the Novel Roles of TRIM56 in Antiviral Innate Immunity, Baoming Liu

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Endosomal Trafficking as a Determinant of Antifungal Tolerance in the Pathogenic Fungus Candida albicans, Arturo Luis Luna

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Role of Occludin in the Regulation of Epithelial Tight Junctions, Bhargavi Manda

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Neuroanatomical Maps and Taste Reactivity to Sweet, Umami, and Bitter Taste in the PBN of C57BL/6J Mice, Jennifer Marie Saputra

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Pten Signaling in Regulatory T Cells and Inflammatory Disease, Sharad Krishna Shrestha

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Evaluating the Therapeutic Effect of an Hsp90 Inhibitor in Mouse Models of Alzheimer’s Disease, Bin Wang

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Dissecting the Physiological Roles of ULK1/2 in the Mouse Brain, Bo Wang

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Understanding Structural And Functional Mechanisms of Emi1 Inhibition of the Anaphase Promoting Complex, Edmond Randall Watson

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Environmental Signaling through the Target of Rapamycin Complex 1 (TORC1) and the Regulation of Epigenetic Mechanisms, Jason J. Workman

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Repeated Zolpidem Treatment Effects on Sedative Tolerance, Withdrawal, mRNA Levels, and Protein Expression, Brittany T. Wright

Theses/Dissertations from 2015

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Genetic Control of Survival and Weight Loss during Pneumonic Burkholderia pseudomallei (Bp) Infection, Felicia D. Emery

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Integration of ATM, ATR, and DNA-PKcs Signaling Maintains Genome Integrity During Neurogenesis, Vanessa D. Enriquez-Rios

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Reprogramming to Pluripotency Using Small Molecule Compounds, Brittany E. Greenberg

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Molecular Mechanisms Underlying AlcoholInduced Cerebral Artery Smooth Muscle BK Channel Inhibition and Eventual Cerebral Vasoconstriction, Guruprasad Kuntamallappanavar

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Adverse Effects of Asparaginase in Pediatric Patients with Acute Lymphoblastic Leukemia, Chengcheng Liu

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Development of Oral Vaccines Against Lyme Disease, Rita Raquel dos Anjos de Carvalho e Melo

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Functional Analysis of Genomic Variation and Impact on Molecular and Higher Order Phenotypes, Ashutosh Kumar Pandey

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Effects of Cocaine Sensitization on Drug Self-Administration, Mesocorticolimbic SAPAP Levels, and Prefrontal Ionotropic Glutamate Receptors, Kyle Christopher Summers

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Structural-based Investigation of FAK and P130Cas in Focal Adhesion, Chi Zhang