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Theses/Dissertations from 2019

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Roles of γδ T Cells in Influenza Infections and Methods for TCR Expression and Characterization, Xizhi Guo

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Investigation of Cell-Type-Specific Effects and Synergistic Interactions Between Genes in Duplication 15q Syndrome, Kevin A. Hope

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Regulation of CYP3A5 in Pancreatic Ductal Adenocarcinoma, Jessica D. Hoyer

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The Role of Secretory Phospholipase A2 Group IIA in Obesity and Metabolism, Michael S. Kuefner

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Transcriptional Regulation of NLRC4 Inflammasome by IRF8, Ein Lee

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Using Genetic Diversity to Understand Susceptibility to Cognitive Decline in Aging and Alzheimer’s Disease, Sarah M. Neuner

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Study of Natural Killer Cells and Their Therapeutic Role in Pediatric Cancer, Hong Ha Rosa Nguyen

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Fear Learning and the Olfactory Bulb: Neural Correlates of Behavioral Fear Generalization, Jordan Marie Ross

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Challenging the Paradigm of Clinical Triazole Resistance in Aspergillus fumigatus, Jeffrey Michael Rybak

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Antibiotic Drug Discovery Targeting Bacterial Metabolism, Miranda J. Wallace

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Investigation of Riluzole’s Synaptic Protection Mechanism Through HSF1-BDNF Axis, Yi Zhang

Theses/Dissertations from 2018

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Characterization of the Hepatotoxicity of Rifampicin and Isoniazid, Christopher T. Brewer

Molecular Interplay of Chromatin Remodeling Factor BRG1 and Transcription Factor STAT3 Regulates Stemness, Chemosensitivity and Tumorigenicity of Glioma Tumor Initiating Cells, Debolina Ganguly

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Understanding the Impact of BCRP and PGP Efflux Transporters on the Disposition of Their Endogenous, Xenobiotic and Dietary Substrates, Samit Ganguly

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The Tumor Microenvironment Regulates Retinoblastoma Cell Survival, Zachary K. Goldsmith

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Signaling Induced by Inflammatory Mediators in the Rodent Pulmonary Microvasculature, Rachel Escue Helms

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The Role of BiP Co-chaperone SIL1 in Marinesco-Sjögren Syndrome Pathogenesis, Viraj Paresh Ichhaporia

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PIP2 Modulation of Afterhyperpolarizations in Magnocellular Supraoptic Neurons, Matthew Karl Kirchner

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The Role of Exosomal Transport of Viral Agents in Persistent HIV Pathogenesis, Benjamin J. Patters

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An Interface of the Taste and Reward Systems in the Brainstem and Its Role in Feeding, Louis Saites

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Role of SMARCE1 and BHLHE40 in Breast Cancer Metastasis, Aarti Sethuraman

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Pathogenicity and Protection Mediated by a Single TCRβ in Experimental Autoimmune Encephalomyelitis, Tianhua Wu

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Protein Trafficking of BK Channel β1 Subunits in Cerebral Artery Myocytes, Xue Zhai

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Roles of Cytosolic Nucleic Acid Sensors in Cancer and Infection, Qifan Zhu

Theses/Dissertations from 2017

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Investigating the Role of Dispatched in Hedgehog Ligand Transport and Delivery, William Bodeen

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Metabolic Regulation of Cellular Signaling, Rashid John Darbandi

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THE ROLE OF HSF1 PROTEIN REGULATION ON NEURODEGENERATION, Eunhee Kim

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Using S. pombe to Study the Biological Roles of the Histone Deacetylases Sir2 and Clr3 and the DEAD-Box RNA Helicase Ded1, Brandon Ray Lowe

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Assessing Neuronal Synchrony and Brain Function Through Local Field Potential and Spike Analysis, Samuel Stuart McAfee

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Habituation and Dishabituation in the Olfactory Bulb: From Neural Responses to Behavior, Mary Cameron Ogg

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Pitx3Null Mutant (Striatal Dopamine-Deficient) Mice Have Exaggerated Spiny Projection Neuron Responses to l-DOPA and D1 Agonism and Lack Baseline Striatonigral Spiking, Ben Sagot

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Role of Dendritic Cells in Pathology of Respiratory Syncytial Virus Infection in Neonates, Bishwas Shrestha

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Biophysical and Biochemical Screening Approaches for Antimicrobial Drug Discovery Targeting S. aureus ClpP, Aman Preet Singh

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Genome-scale Precision Proteomics Identifies Cancer Signaling Networks and Therapeutic Vulnerabilities, Hong Wang

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Revealing a Non-canonical Role of Anti-apoptotic MCL-1 in Early Embryonic Development, Xue Yang

Theses/Dissertations from 2016

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Interaction Between Two E3 ligases, NEDD8ylated Cullin and HHARI, Kheewoong Baek

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Investigating the Regulation and Function of the NR4A Nuclear Receptors in Cancer, Jordan A. Beard

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The Nucleolar Protein Nucleophosmin Undergoes Liquid-Liquid Phase Separation with Arginine-Rich Nucleolar Proteins through Weak, Multivalent Electrostatic Interactions, Jaclyn Alicia Cika

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Novel Oncogenic Drivers in Pediatric Gliomagenesis, Alexander K. Diaz

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Antibodies to Heterogenous Nuclear Ribonucleoprotein A1 Penetrate Neurons Leading to Multiple Downstream Effects Resulting in Neurodegeneration, Joshua Nathan Douglas

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Assessment of the Zoonotic Potential of a Novel Bovine Influenza Virus, Laura Evelyn Eckard

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The Roles of Nuclear Receptor NR4A1 in Cancer Cell Proliferation and Skeletal Muscle Differentiation, Alexa Farmer

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Examining the Roles of GABAA Receptor Subtypes in Anxiety and Anxiolysis: Focusing on the Basolateral Amygdala, Yudong Gao

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Mild Traumatic Brain Injury with Associated Visual System Dysfunction: Investigating Histopathology, Functional Correlates, and a Novel Therapeutic Immune Modulator, Natalie M. Guley

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The Role of Drak2 in T Cell Function and Autoimmunity, Tarsha L. Harris

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Regulation of IRF-3-Dependent Innate Immune Signaling Pathway by the PLpro Domain of Non-Structural Protein 3 (NSP3) of Severe Acute Respiratory Syndrome (SARS) Coronavirus, Sandra Nicole Lester

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Dissecting the Novel Roles of TRIM56 in Antiviral Innate Immunity, Baoming Liu

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Endosomal Trafficking as a Determinant of Antifungal Tolerance in the Pathogenic Fungus Candida albicans, Arturo Luis Luna

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Role of Occludin in the Regulation of Epithelial Tight Junctions, Bhargavi Manda

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Neuroanatomical Maps and Taste Reactivity to Sweet, Umami, and Bitter Taste in the PBN of C57BL/6J Mice, Jennifer Marie Saputra

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Pten Signaling in Regulatory T Cells and Inflammatory Disease, Sharad Krishna Shrestha

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Evaluating the Therapeutic Effect of an Hsp90 Inhibitor in Mouse Models of Alzheimer’s Disease, Bin Wang

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Dissecting the Physiological Roles of ULK1/2 in the Mouse Brain, Bo Wang

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Understanding Structural And Functional Mechanisms of Emi1 Inhibition of the Anaphase Promoting Complex, Edmond Randall Watson

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Environmental Signaling through the Target of Rapamycin Complex 1 (TORC1) and the Regulation of Epigenetic Mechanisms, Jason J. Workman

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Repeated Zolpidem Treatment Effects on Sedative Tolerance, Withdrawal, mRNA Levels, and Protein Expression, Brittany T. Wright

Theses/Dissertations from 2015

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Genetic Control of Survival and Weight Loss during Pneumonic Burkholderia pseudomallei (Bp) Infection, Felicia D. Emery

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Integration of ATM, ATR, and DNA-PKcs Signaling Maintains Genome Integrity During Neurogenesis, Vanessa D. Enriquez-Rios

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Reprogramming to Pluripotency Using Small Molecule Compounds, Brittany E. Greenberg

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Molecular Mechanisms Underlying AlcoholInduced Cerebral Artery Smooth Muscle BK Channel Inhibition and Eventual Cerebral Vasoconstriction, Guruprasad Kuntamallappanavar

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Adverse Effects of Asparaginase in Pediatric Patients with Acute Lymphoblastic Leukemia, Chengcheng Liu

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Development of Oral Vaccines Against Lyme Disease, Rita Raquel dos Anjos de Carvalho e Melo

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Functional Analysis of Genomic Variation and Impact on Molecular and Higher Order Phenotypes, Ashutosh Kumar Pandey

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Effects of Cocaine Sensitization on Drug Self-Administration, Mesocorticolimbic SAPAP Levels, and Prefrontal Ionotropic Glutamate Receptors, Kyle Christopher Summers

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Structural-based Investigation of FAK and P130Cas in Focal Adhesion, Chi Zhang

Theses/Dissertations from 2014

Preclinical Evaluation of a Novel Polysaccharide Hydrogel for Local Chemotherapy Delivery to Solid Tumors, Elizabeth Diana Barker

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Adenosine Production Is Essential for Closing the Critical Period of Cortical Plasticity, Rachel A. Chassan

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The Mi-2 Homolog Mit1 Actively Positions Nucleosomes Within Heterochromatin to Suppress Transcription, Kevin M. Creamer

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Molecular Characterization of Glioblastoma Cancer Stem Cells, Jo Meagan Garner

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Functional and Genetic Analysis of Choroid Plexus Development in Zebrafish, Hannah Elizabeth Henson

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Preliminary Study on How Tumor Suppressor Nf2 Inhibits Transcriptional Coactivators Yap/Taz in the Developing Mouse Brain, Yu He

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Group IV Cytosolic Phospholipase A2α Is Critical for the Development of Angiotensin II-Induced Hypertension and Associated Pathogenesis, Nayaab Shehbaz Khan

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Effect of Nedd4 Haploinsufficiency on Insulin Sensitivity, Adiposity and Neuronal Behaviors, Jingjing Li

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Persistant GATA2 Expression Promotes Self-Renewal of Myeloid Progenitors and Blocks Lymphoid Differentiation., Satish Kumar Nandakumar

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Novel Insights into the Role of the Smoothened Cysteine Rich Domain in Hedgehog Signalling, Rajashree Rana

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Characterization of Cre Mouse Models to Target CNS Barriers for Generating Conditional Knockouts of ABC Transporters, Rachel L. Scheib

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MRP4-Dependent Regulation of Fibroblast Migration, Chandrima Sinha

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Genetic and Chemical Dissection of BloodBrain Barrier Development in Zebrafish, Robyn Anne Umans

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The Role of MCL-1 in the Heart: Gateway from Life to Death, Xi Wang

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Strengths and Weaknesses of Hybrid TPR Technology for Obtaining Structural and Mechanistic Insights into TPR Proteins, Shanshan Yu

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Autoimmune Susceptibility Imposed by Public TCRβ Chains, Yunqian Zhao

Theses/Dissertations from 2013

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Toll-like Receptors 2 and 9 Are Important for Innate Immune Cell Activation and Recruitment in Hypersensitivity Pneumonitis, Kelly J. Andrews

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Macromolecular Complexes of Cystic Fibrosis Transmembrane Conductance Regulator Alter Fluid Transport in inflammatory Bowel Disorders, Kavisha Arora

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Adenylyl Cyclase 2 Selectively Regulates IL-6 Expression in Human Bronchial Smooth Muscle Cells, Amy Sue Bogard

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Development and Characterization of a Recombinant Vesicular Stomatitis Virus (rVSV) for the Treatment of Glioblastoma, Erika A. Dillard

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Virologic Factors Contributing to the Genetic Diversification of Influenza Viruses Circulating in North American Swine, Thomas Paul Fabrizio II

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ERG11-Mediated Azole Resistance in Candida albicans, Stephanie Ann Flowers

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Functional Study of Hemogen Knockout Mouse Model, Peng Gao

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A Novel Mechanism of Enhanced Susceptibility to Bacterial Pneumonia in Influenza-infected Hosts, Hazem Elsayed Ghoneim

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NKG2D Ligands in Cancer, Neha Das Gupta

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Developmental Characterization of the Choroid Plexus in Sialidosis (Neu1 Deficient) Mice, Danielle Lee Helton

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Tetraspanin CD9: Contributions to Cancer Cell and Vascular Cell Phenotypes from the Sixth Man, Michael James Herr II

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Determinants of Upper Genital Tract Complications in a Chlamydial Urogenital Mouse Model, Enitra N. Jones

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In vitro and In vivo Characterization of the Infection Efficiency of a Modified Retrovirus Envelope Glycoprotein for Targeting Gene Transduction, Robin L. Krueger

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Identification of Novel HIF1A Target Genes That Regulate Tumor Progression and Metastasis, Danielle L. Peacock

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Full-Gestational Exposure to Nicotine and Ethanol Results in Long-Term Dysregulation in the Ventral Tegmental Area, Emily Elizabeth Roguski

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Regulation of Secretory Phospholipase A2 by Thyroid Hormone, Pragya Sharma

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Attenuation of Parenteral NutritionAssociated Liver Disease by Omega-3 Long-Chain Polyunsaturated Fatty Acids, Emma Monique Tillman

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The Protumorigenic Role of Caspase-8 in Neuroblastoma, Devin Drew Twitchell

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Signal Transduction and Transcriptional Regulation Pathways Essential for Azole Resistance in Candida albicans, Erin M. Vasicek